Effect of caffeine on ventricular arrhythmia: a systematic review and meta-analysis of experimental and clinical studies
Zuchinali P, Ribeiro PA, Pimentel M, da Rosa PR, Zimerman LI, Rohde LE
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 29 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-10-05 · Europace · vol. 18 · número 2 · págs. 257–266
- Editorial
- Oxford University Press
- Citado
- 40 citas · más que el 65% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Cardiac electrophysiology and arrhythmias · Cardiac Arrhythmias and Treatments
- Palabras clave
- caffeine, ventricular arrhythmias, premature ventricular contractions, ventricular fibrillation threshold, coffee consumption, caffeine dose, animal studies
- MeSH
- heart conduction system, animals, humans, ventricular premature complexes, caffeine, central nervous system stimulants, odds ratio, risk assessment, risk factors, heart rate
6 autores
- Priccila Zuchinali
- Paula Aver Bretanha Ribeiro
- Maurício Pimentel🇧🇷Hospital de Clínicas de Porto Alegre
- Priscila Raupp da Rosa🇧🇷Hospital São Lucas da PUCRS; Pontifícia Universidade Católica do Rio Grande do Sul
- Leandro Ioschpe Zimerman🇧🇷Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
- Luís Eduardo Paim Rohde🇧🇷 · autor de correspondenciaUniversidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
The relationship between caffeine consumption and the occurrence of arrhythmias remains controversial. Despite this lack of scientific evidence, counselling to reduce caffeine consumption is still widely advised in clinical practice. We conducted a systematical review and meta-analysis of interventional studies of the caffeine effects on ventricular arrhythmias.
Methods and results
The search was performed on Pubmed, Embase, and Cochrane database, and terms related to coffee, caffeine, and cardiac arrhythmias were used. Methodological quality was assessed based on The Cochrane Collaboration recommendations and the ARRIVE guidelines. There were 2016 citations retrieved on the initial research. After full-text assessment, seven human and two animal studies were included in the meta-analysis. In animal studies, the main outcome reported was the ventricular fibrillation threshold. We observed a significant mean difference of -2.15 mA (95% CI -3.43 to -0.87; I(2) 0.0%, P for heterogeneity = 0.37). The main outcome evaluated in human studies was the rate of ventricular premature beats (VPBs). The overall relative risk for occurrence of VPBs in 24 h attributed to caffeine exposure was 1.00 (95% CI 0.94-1.06; I(2) 13.5%, P for heterogeneity = 0.32). Sensitivity analysis for caffeine dose, different designs, and subject profile was performed and no major differences were observed.
Conclusion
Our meta-analysis demonstrates that data from human interventional studies do not show a significant effect of caffeine consumption on the occurrence of VBPs. The effects observed in animal studies are most probably the result of very high caffeine doses that are not regularly consumed in a daily basis by humans.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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