A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women
Storniolo CE, Casillas R, Bulló M, Castañer O, Ros E, Sáez GT, Toledo E, Estruch R, Ruiz-Gutiérrez V, Fitó M, Martínez-González MA, Salas-Salvadó J, Mitjavila MT, Moreno JJ
European journal of nutrition · 79 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Spanish Ministry of Science
- Gobierno
- Spanish Ministry of Health
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-10-08 · Eur J Nutr · vol. 56 · número 1 · págs. 89–97
- Editorial
- Springer Science+Business Media
- Citado
- 123 citas · más que el 97% de estudios similares · 6.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Nutritional Studies and Diet · Cardiovascular Health and Disease Prevention
- Palabras clave
- Mediterranean diet, extra virgin olive oil, nuts, hypertension, blood pressure, endothelial dysfunction, nitric oxide, endothelin-1, endothelin-1 receptor, endothelial nitric oxide synthase, caveolin-2, gene expression, oxidative stress, women
- MeSH
- humans, nuts, hypertension, body weight, nitric oxide, blood glucose, triglycerides, endothelin-1, receptor, endothelin a, body mass index, diet, fat-restricted, risk factors, life style, gene expression regulation, diet, mediterranean, blood pressure, aged, aged, 80 and over, middle aged, female, cholesterol, ldl, cholesterol, hdl, waist circumference, biomarkers, olive oil, surveys and questionnaires
14 autores
- Carolina Emilia Storniolo🇪🇸Universitat de Barcelona
- Rosario Casillas🇪🇸Universitat de Barcelona
- Mònica Bulló🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universitat Rovira i Virgili
- Olga Castañer🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Del Mar; Municipal Institute for Medical Research; Hospital del Mar Research Institute
- Emilio Ros🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Clínic de Barcelona
- Guillermo T. Sáez🇪🇸Universitat de València; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- Estefanía Toledo🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universidad de Navarra
- Ramón Estruch🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universitat de Barcelona
- Valentina Ruíz-Gutiérrez🇪🇸Consejo Superior de Investigaciones Científicas; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Instituto de la Grasa
- Montserrat Fitó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Del Mar; Municipal Institute for Medical Research; Hospital del Mar Research Institute
- Miguel Ángel Martínez‐González🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universidad de Navarra
- Jordi Salas‐Salvadó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universitat Rovira i Virgili
- Maria Teresa Mitjavila🇪🇸Universitat de Barcelona
- Juan Jose Moreno🇪🇸 · autor de correspondenciaUniversitat de Barcelona
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure (BP), the aim of this study was to analyze whether TMD induced changes on endothelial physiology elements such as NO, ET-1 and ET-1 receptors which are involved in BP control.
Methods
Non-smoking women with moderate hypertension were submitted for 1 year to interventions promoting adherence to the TMD, one supplemented with extra virgin olive oil (EVOO) and the other with nuts versus a control low-fat diet (30 participants/group). BP, NO, ET-1 and related gene expression as well as oxidative stress biomarkers were measured.
Results
Serum NO and systolic BP (SBP) or diastolic BP (DBP) were negatively associated at baseline, as well as between NO and ET-1. Our findings also showed a DBP reduction with both interventions. A negative correlation was observed between changes in NO metabolites concentration and SBP or DBP after the intervention with TMD + EVOO (p = 0.033 and p = 0.044, respectively). SBP reduction was related to an impairment of serum ET-1 concentrations after the intervention with TMD + nuts (p = 0.008). We also observed changes in eNOS, caveolin 2 and ET-1 receptors gene expression which are related to NO metabolites levels and BP.
Conclusions
The changes in NO and ET-1 as well as ET-1 receptors gene expression explain, at least partially, the effect of EVOO or nuts on lowering BP among hypertensive women.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.