Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols
Liu Y, Zhang D, Hu J, Liu G, Chen J, Sun L, Jiang Z, Zhang X, Chen Q, Ji B
Journal of agricultural and food chemistry · 26 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Key Technology R&D Program for the twelfth 5-year plan
- Subvenciones
- National Natural Science Foundation of China (project no. 31571831)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-10-12 · J Agric Food Chem · vol. 63 · número 42 · págs. 9295–9305
- Editorial
- American Chemical Society
- Citado
- 44 citas · más que el 91% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Retinal Diseases and Treatments · Antioxidant Activity and Oxidative Stress · Retinal Development and Disorders
- Palabras clave
- Lipid peroxidation, Docosahexaenoic acid, Retinal, Polyphenol, Biochemistry, Arachidonic acid, Chemistry, Anthocyanin, Flavonoid, Antioxidant, Retina, Fatty acid, Polyunsaturated fatty acid, Food science, Biology, Enzyme
- MeSH
- retina, animals, rabbits, humans, retinal diseases, fatty acids, unsaturated, plant extracts, lipid peroxidation, light, dietary supplements, polyphenols, blueberry plants
10 autores
- Yixiang Liu🇨🇳Jimei University
- Di Zhang🇨🇳Jiangsu University
- Jimei Hu🇨🇳China Agricultural University
- Guangming Liu🇨🇳Jimei University
- Jun Chen🇨🇳Jimei University
- Le‐Chang Sun🇨🇳Jimei University
- Zedong Jiang🇨🇳Jimei University
- Xichun Zhang🇨🇳Jimei University
- Qingchou Chen🇨🇳Jimei University
- Baoping Ji🇨🇳 · autor de correspondenciaChina Agricultural University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The lipid peroxidation of unsaturated fatty acids (UFAs) in the retina not only threatens visual cells but also affects the physiological health of the retina. In this work, the potential damages caused by daily visible light exposure on retinal UFAs were evaluated via a simulated in vitro model. At the same time, the benefits of dietary supplementation of blueberries to the eyes were also assessed. After prolonged light exposure, lipid peroxidation occurred for both docosahexaenoic and arachidonic acids (DHA and AA, respectively). The oxidized UFAs presented obvious cytotoxicity and significantly inhibited cell growth in retinal pigment epithelium cells. Among the different blueberry polyphenol fractions, the flavonoid-rich fraction, in which quercetin was discovered as the main component, was considerably better in preventing visible light-induced DHA lipid peroxidation than the anthocyanin- and phenolic acid-rich fractions. Then the retinal protective activity of blueberry polyphenols against light-induced retinal injury was confirmed in vivo. On the basis of the above results, inhibiting lipid peroxidation of UFAs in the retina is proposed to be another important function mechanism for antioxidants to nourish eyes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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