Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity
Tolba MF, Abdel-Rahman SZ
Scientific reports · 42 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-10-16 · Sci Rep · vol. 5 · número 1 · pág. 15239
- Editorial
- Nature Portfolio
- Citado
- 55 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- FOXO transcription factor regulation · Plant tissue culture and regeneration · PI3K/AKT/mTOR signaling in cancer
- Palabras clave
- Colorectal cancer, Cytotoxic T cell, Caco-2, Cytotoxicity, Cancer research, Apoptosis, Fluorouracil, Cancer cell, Toxicity, Chemistry, Protein kinase B, Pharmacology, Medicine, Cancer, Internal medicine, Cell, Biochemistry, In vitro
- MeSH
- caco-2 cells, hct116 cells, humans, colonic neoplasms, stilbenes, fluorouracil, mitogen-activated protein kinase 1, mitogen-activated protein kinase 3, estrogen receptor beta, antineoplastic agents, apoptosis, binding sites, catalytic domain, phosphorylation, drug synergism, cyclin-dependent kinase inhibitor p27, proto-oncogene proteins c-akt, forkhead transcription factors, cell cycle checkpoints, molecular docking simulation, blueberry plants, forkhead box protein o1
2 autores
- Mai Fathy Tolba🇪🇬Ain Shams University; American University in Cairo
- Sherif Z. Abdel‐Rahman🇺🇸The University of Texas Medical Branch at Galveston
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although colorectal cancer (CRC) treatment with 5-fluorouracil (5-FU) is the first line of therapy for this debilitating disease, treatment effectiveness is often hampered by the development of drug resistance and toxicity at high doses. ER-β can play an important role in CRC development and possibly in its response to therapy. Pterostilbene (PT) possesses antioxidant and anticancer effects that are mediated by ER-β. In the current study, we test the hypothesis that PT sensitizes colon cancer cells to 5-FU and we examine the underlying mechanism(s) by which PT exerts its cytotoxic effects in CRC cells. Our data indicate that PT exhibited a more potent cytotoxic effect in Caco-2 compared to HCT-116 cells. PT/5-FU co-treatment was more effective in Caco-2 cells. Our data indicate that ER-β is expressed at higher levels in Caco-2 cells and its levels are further boosted with PT treatment. PT significantly suppressed Akt and ERK phosphorylations, and enhanced FOXO-1 and p27(kip1) levels in Caco-2 cells. PT also induced a significant increase in Caco-2 cells at pre-G phase coupled with increased Bax/Bcl-2 ratio and PARP cleavage. These results provide a rationale for novel combination treatment strategies, especially for patients with 5-FU-resistant tumors expressing ER-β protein.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.