Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds
Panahi Y, Izadi M, Sayyadi N, Rezaee R, Jonaidi-Jafari N, Beiraghdar F, Zamani A, Sahebkar A
Journal of wound care · 35 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-10-02 · J Wound Care · vol. 24 · número 10 · págs. 459–465
- Editorial
- Mark Allen Group
- Citado
- 60 citas · más que el 94% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Wound Healing and Treatments · Phytochemistry and biological activity of medicinal plants · Pressure Ulcer Prevention and Management
- Palabras clave
- Medicine, Aloe vera, Visual analogue scale, Wound healing, Randomized controlled trial, Surgery, Traditional medicine
- MeSH
- humans, aloe, pain, wounds and injuries, chronic disease, phenytoin, plant preparations, anti-infective agents, pain measurement, treatment outcome, phytotherapy, drug therapy, combination, double-blind method, wound healing, olive oil
8 autores
- Yunes Panahi🇮🇷Baqiyatallah University of Medical Sciences
- Morteza Izadi🇮🇷Baqiyatallah University of Medical Sciences
- N. Sayyadi🇮🇷Islamic Azad University Pharmaceutical Sciences Branch
- Ramin Rezaee🇮🇷North Khorasan University of Medical Sciences
- Nematollah Jonaidi Jafari🇮🇷Baqiyatallah University of Medical Sciences
- Fatemeh Beiraghdar🇮🇷Baqiyatallah University of Medical Sciences
- Ali Zamani🇮🇷Baqiyatallah University of Medical Sciences
- Amirhossein Sahebkar🇮🇷🇦🇺Mashhad University of Medical Sciences; The University of Western Australia; Royal Perth Hospital; Biotechnology Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Aloe vera is a medicinal plant that has been traditionally used to accelerate wound healing. Olive oil is also a natural product that may contribute to wound healing owing to its antimicrobial and anti-inflammatory effects. The present study aimed to evaluate the effect of an Aloe vera-olive oil (AVO) combination cream on the healing process of chronic wounds.
Method
In this randomised, double-blind, comparator-controlled, parallel-group trial, patients with chronic wounds were treated with either AVO cream or phenytoin cream as the standard treatment for a period of 30 days. Wound healing was evaluated using Bates-Jensen assessment tool and the severity of pain was assessed using a visual analogue scale (VAS).
Results
After initial assessment, 60 patients with chronic wounds (41 with pressure ulcer, 13 with diabetic wounds and 6 with venous ulcers), were recruited and randomised into 2 groups of 30. After 30 days of treatment, significant improvements in the wound size, depth, and edges; necrotic tissue type and amount; exudate type and amount; colour of wound surroundings; and peripheral tissue oedema score were observed in the AVO cream group (p<0.001). The total score of wound healing showed significant improvement with both AVO (p<0.001) and phenytoin (p<0.01) creams, although AVO was more efficacious (p<0.001). Likewise, although both treatments reduced the initial VAS score, the efficacy of AVO was significantly greater (p<0.001).
Conclusion
AVO cream significantly accelerates biological healing of chronic wounds and helps to reduce pain severity with a higher efficacy compared with phenytoin cream.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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