Impairments in central cardiovascular function contribute to attenuated reflex vasodilation in aged skin
Greaney JL, Stanhewicz AE, Proctor DN, Alexander LM, Kenney WL
Journal of applied physiology (Bethesda, Md. : 1985) · 29 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Pennsylvania State University
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
- Gobierno
- HHS | NIH | National Institute on Aging (U.S. National Institute on Aging)
- Gobierno
- NIA NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL-093-238-04); National Heart, Lung, and Blood Institute (HL120471-01); National Heart, Lung, and Blood Institute (HL093238); National Heart, Lung, and Blood Institute (HL120471); National Institute on Aging (AG007004); National Institute on Aging (AG007004-23); National Heart, Lung, and Blood Institute (R01-HL093238)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2015-10-23 · J Appl Physiol (1985) · vol. 119 · número 12 · págs. 1411–1420
- Editorial
- American Physiological Society
- Citado
- 30 citas · más que el 82% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Thermoregulation and physiological responses · Climate Change and Health Impacts · Heart Rate Variability and Autonomic Control
- Palabras clave
- Supine position, Medicine, Vasodilation, Internal medicine, Peripheral, Placebo, Cardiac output, Anesthesia, Crossover study, Hemodynamics, Cardiology
- MeSH
- skin, humans, cardiac output, reflex, body temperature, exercise, cross-over studies, double-blind method, central venous pressure, vasodilation, skin aging, supine position, aged, female, male, hemodynamics, hot temperature, young adult, biopterins
5 autores
- Jody L. Greaney🇺🇸 · autor de correspondenciaPennsylvania State University
- Anna E. Stanhewicz🇺🇸Pennsylvania State University
- David N. Proctor🇺🇸Pennsylvania State University
- Lacy M. Alexander🇺🇸Pennsylvania State University
- W. Larry Kenney🇺🇸Pennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
During supine passive heating, increases in skin blood flow (SkBF) and cardiac output (Qc) are both blunted in older adults. The aim here was to determine the effect of acutely correcting the peripheral vasodilatory capacity of aged skin on the integrated cardiovascular responses to passive heating. A secondary aim was to examine the SkBF-Qc relation during hyperthermia in the presence (upright posture) and absence (dynamic exercise) of challenges to central venous pressure. We hypothesized that greater increases in SkBF would be accompanied by greater increases in Qc. Eleven healthy older adults (69 ± 3 yr) underwent supine passive heating (0.8°C rise in core temperature; water-perfused suit) after ingesting sapropterin (BH4, a nitric oxide synthase cofactor; 10 mg/kg) or placebo (randomized double-blind crossover design). Twelve young (24 ± 1 yr) subjects served as a comparison group. SkBF (laser-Doppler flowmetry) and Qc (open-circuit acetylene wash-in) were measured during supine heating, heating + upright posture, and heating + dynamic exercise. Throughout supine and upright heating, sapropterin fully restored the SkBF response of older adults to that of young adults but Qc remained blunted. During heat + upright posture, SkBF failed to decrease in untreated older subjects. There were no age- or treatment-related differences in SkBF-Qc during dynamic exercise. The principal finding of this study was that the blunted Qc response to passive heat stress is directly related to age as opposed to the blunted peripheral vasodilatory capacity of aged skin. Furthermore, peripheral impairments to SkBF in the aged may contribute to inapposite responses during challenges to central venous pressure during hyperthermia.
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