No Effect of Omega-3 Fatty Acid Supplementation on Cognition and Mood in Individuals with Cognitive Impairment and Probable Alzheimer's Disease: A Randomised Controlled Trial
Phillips MA, Childs CE, Calder PC, Rogers PJ
International journal of molecular sciences · 103 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Alexander and Margaret Stewart Trust
- Organización sin fines de lucro
- Sir Halley Stewart Trust
- Universidad u hospital
- University of Bristol
- Universidad u hospital
- North Bristol NHS Trust
- Organización sin fines de lucro
- The Sir Halley Stewart Trust
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-10-16 · Int J Mol Sci · vol. 16 · número 10 · págs. 24600–24613
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 149 citas · más que el 99% de estudios similares · 10.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Palabras clave
- omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, dietary supplementation, cognitive impairment, Alzheimer's disease, cognition, mood, polyunsaturated fatty acids, olive oil placebo
- MeSH
- humans, alzheimer disease, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, double-blind method, affect, cognition disorders, dietary supplements, aged, female, male
4 autores
- Michelle Phillips🇬🇧 · autor de correspondenciaUniversity of Bristol
- Caroline E. Childs🇬🇧University of Southampton
- Philip C. Calder🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; University of Southampton
- Peter J. Rogers🇬🇧University of Bristol
Resumen
El texto original del estudio, en el idioma en que se publicó.
Findings from epidemiological and observational studies have indicated that diets high in omega-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) may reduce the risk of cognitive decline and Alzheimer's disease (AD). To determine if increasing intake of DHA and EPA through supplementation is beneficial to cognition and mood in individuals with cognitive impairment no dementia (CIND) or Alzheimer's disease (AD) a four month, randomised, double-blind, placebo controlled study was conducted. Fifty-seven participants with CIND and nineteen with AD were randomised to receive either omega-3 PUFAs (600 mg EPA and 625 mg DHA per day) or placebo (olive oil) over a four month period. Elevating depleted levels of EPA and DHA through supplementation in individuals with CIND or AD was found to have negligible beneficial effect on their cognition or mood. These findings confirm an overall negligible benefit of omega-3 PUFA supplementation for those with cognitive impairment and dementia. More intervention studies need to be undertaken with longer study durations and larger sample sizes. It may prove fruitful to examine effects of different doses as well as effects in other dementia subtypes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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