A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy
Owens DJ, Sharples AP, Polydorou I, Alwan N, Donovan T, Tang J, Fraser WD, Cooper RG, Morton JP, Stewart C, Close GL
American journal of physiology. Endocrinology and metabolism · 104 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-10-27 · Am J Physiol Endocrinol Metab · vol. 309 · número 12 · págs. E1019–E1031
- Editorial
- American Physiological Society
- Citado
- 155 citas · más que el 98% de estudios similares · 7.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Muscle Physiology and Disorders · Exercise and Physiological Responses
- Palabras clave
- vitamin D, 25-hydroxyvitamin D, skeletal muscle regeneration, muscle repair, muscle hypertrophy, eccentric exercise, muscle damage, vitamin D3 supplementation, myoblasts, myotube fusion, myotube differentiation, mechanical damage, 1,25-dihydroxyvitamin D3
- MeSH
- muscle, skeletal, humans, hypertrophy, vitamin d, administration, oral, systems biology, placebo effect, regeneration, dietary supplements, adolescent, adult, physical exertion, young adult
11 autores
- Daniel J. Owens🇬🇧Liverpool John Moores University
- Adam Philip Sharples🇬🇧Liverpool John Moores University
- Ioanna Polydorou🇬🇧Liverpool John Moores University
- Nura Alwan🇬🇧Liverpool John Moores University
- Timothy F. Donovan🇬🇧Wrexham University
- JONATHAN C. Y. TANG🇬🇧University of East Anglia
- William Duncan Fraser🇬🇧University of East Anglia
- Robert G Cooper🇬🇧University of Liverpool; Arthritis Research UK; Medical Research Council
- James Peter Morton🇬🇧Liverpool John Moores University
- Claire Elizabeth Stewart🇬🇧Liverpool John Moores University
- Graeme Leonard Close🇬🇧 · autor de correspondenciaLiverpool John Moores University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Skeletal muscle is a direct target for vitamin D. Observational studies suggest that low 25[OH]D correlates with functional recovery of skeletal muscle following eccentric contractions in humans and crush injury in rats. However, a definitive association is yet to be established. To address this gap in knowledge in relation to damage repair, a randomised, placebo-controlled trial was performed in 20 males with insufficient concentrations of serum 25(OH)D (45 ± 25 nmol/l). Prior to and following 6 wk of supplemental vitamin D3 (4,000 IU/day) or placebo (50 mg of cellulose), participants performed 20 × 10 damaging eccentric contractions of the knee extensors, with peak torque measured over the following 7 days of recovery. Parallel experimentation using isolated human skeletal muscle-derived myoblast cells from biopsies of 14 males with low serum 25(OH)D (37 ± 11 nmol/l) were subjected to mechanical wound injury, which enabled corresponding in vitro studies of muscle repair, regeneration, and hypertrophy in the presence and absence of 10 or 100 nmol 1α,25(OH)2D3. Supplemental vitamin D3 increased serum 25(OH)D and improved recovery of peak torque at 48 h and 7 days postexercise. In vitro, 10 nmol 1α,25(OH)2D3 improved muscle cell migration dynamics and resulted in improved myotube fusion/differentiation at the biochemical, morphological, and molecular level together with increased myotube hypertrophy at 7 and 10 days postdamage. Together, these preliminary data are the first to characterize a role for vitamin D in human skeletal muscle regeneration and suggest that maintaining serum 25(OH)D may be beneficial for enhancing reparative processes and potentially for facilitating subsequent hypertrophy.
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