Financiado en parte por Eli Lilly and Company, Pfizer, Consumer Healthcare Products Association, Natural Products Association, Council for Responsible Nutrition
Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation
Weaver CM, Alexander DD, Boushey CJ, Dawson-Hughes B, Lappe JM, LeBoff MS, Liu S, Looker AC, Wallace TC, Wang DD
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 381 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Empresa
- Eli Lilly and Company
- Empresa
- Pfizer
- Grupo de la industria
- Consumer Healthcare Products Association
- Gobierno
- Agency for Healthcare Research and Quality
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- National Institute of Child Health and Human Development
- Gobierno
- NIAMS NIH HHS
- Grupo de la industria
- Natural Products Association
- Grupo de la industria
- Council for Responsible Nutrition
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059775)
Según 11 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-10-28 · Osteoporos Int · vol. 27 · número 1 · págs. 367–376
- Editorial
- Springer Science+Business Media
- Citado
- 615 citas · más que el 100% de estudios similares · 26.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Nutrition and Health Studies
- Palabras clave
- calcium supplementation, vitamin D supplementation, fracture prevention, hip fracture, osteoporosis, fracture risk reduction, older adults, Women's Health Initiative
- MeSH
- humans, osteoporosis, postmenopausal, calcium, vitamin d, drug therapy, combination, risk assessment, dietary supplements, bone density conservation agents, randomized controlled trials as topic, osteoporotic fractures
10 autores
- Connie M. Weaver🇺🇸Purdue University West Lafayette
- Dominik D. Alexander
- Carol J. BousheyUniversity of Hawaii Cancer Center
- Bess Dawson‐Hughes🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Joan M. Lappe🇺🇸Creighton University
- Meryl Susan LeBoff🇺🇸Brigham and Women's Hospital; Harvard University
- S. Liu🇺🇸Tufts University
- Anne C. Looker🇺🇸Centers for Disease Control and Prevention; National Center for Health Statistics
- Taylor C. Wallace🇺🇸 · autor de correspondenciaGeorge Mason University; Bone Health and Osteoporosis Foundation
- D. D. Wang🇺🇸Tufts University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
The aim was to meta-analyze randomized controlled trials of calcium plus vitamin D supplementation and fracture prevention. Meta-analysis showed a significant 15 % reduced risk of total fractures (summary relative risk estimate [SRRE], 0.85; 95 % confidence interval [CI], 0.73-0.98) and a 30 % reduced risk of hip fractures (SRRE, 0.70; 95 % CI, 0.56-0.87).
Introduction
Calcium plus vitamin D supplementation has been widely recommended to prevent osteoporosis and subsequent fractures; however, considerable controversy exists regarding the association of such supplementation and fracture risk. The aim was to conduct a meta-analysis of randomized controlled trials [RCTs] of calcium plus vitamin D supplementation and fracture prevention in adults.
Methods
A PubMed literature search was conducted for the period from July 1, 2011 through July 31, 2015. RCTs reporting the effect of calcium plus vitamin D supplementation on fracture incidence were selected from English-language studies. Qualitative and quantitative information was extracted; random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for total and hip fractures. Statistical heterogeneity was assessed using Cochran's Q test and the I (2) statistic, and potential for publication bias was assessed.
Results
Of the citations retrieved, eight studies including 30,970 participants met criteria for inclusion in the primary analysis, reporting 195 hip fractures and 2231 total fractures. Meta-analysis of all studies showed that calcium plus vitamin D supplementation produced a statistically significant 15 % reduced risk of total fractures (SRRE, 0.85; 95 % confidence interval [CI], 0.73-0.98) and a 30 % reduced risk of hip fractures (SRRE, 0.70; 95 % CI, 0.56-0.87). Numerous sensitivity and subgroup analyses produced similar summary associations. A limitation is that this study utilized data from subgroup analysis of the Women's Health Initiative.
Conclusions
This meta-analysis of RCTs supports the use of calcium plus vitamin D supplements as an intervention for fracture risk reduction in both community-dwelling and institutionalized middle-aged to older adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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