Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies
Grosso G, Micek A, Castellano S, Pajak A, Galvano F
Molecular nutrition & food research · 168 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-10-31 · Mol Nutr Food Res · vol. 60 · número 1 · págs. 223–234
- Editorial
- Wiley
- Citado
- 235 citas · más que el 85% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Coffee research and impacts · Tea Polyphenols and Effects · Heavy Metals in Plants
- Palabras clave
- Caffeine, Medicine, Meta-analysis, Depression (economics), Confidence interval, Relative risk, Observational study, Odds ratio, Internal medicine, Publication bias, Subgroup analysis, Lower risk
- MeSH
- humans, caffeine, risk factors, depression, dose-response relationship, drug, coffee, tea, databases, factual, observational studies as topic
5 autores
- Giuseppe Grosso🇮🇹 · autor de correspondenciaUniversity of Catania
- Agnieszka Micek🇵🇱Jagiellonian University
- Sabrina Castellano🇮🇹University of Catania
- Andzrej Pajak🇵🇱Jagiellonian University
- Fabio Galvano🇮🇹University of Catania
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
The aim of the study was to systematically review and analyze results from observational studies on coffee, caffeine, and tea consumption and association or risk of depression.
Methods and results
Embase and PubMed databases were searched from inception to June 2015 for observational studies reporting the odds ratios or relative risks (RRs) and 95% confidence intervals (CI) of depression by coffee/tea/caffeine consumption. Random effects models, subgroup analyses, and dose-response analyses were performed. Twelve studies with 23 datasets were included in the meta-analysis, accounting for a total of 346 913 individuals and 8146 cases of depression. Compared to individuals with lower coffee consumption, those with higher intakes had pooled RR of depression of 0.76 (95% CI: 0.64, 0.91). Dose-response effect suggests a nonlinear J-shaped relation between coffee consumption and risk of depression with a peak of protective effect for 400 mL/day. A borderline nonsignificant association between tea consumption and risk of depression was found (RR 0.70, 95% CI: 0.48, 1.01), while significant results were found only for analysis of prospective studies regarding caffeine consumption (RR = 0.84, 95% CI: 0.75, 0.93).
Conclusion
This study suggests a protective effect of coffee and, partially, of tea and caffeine on risk of depression.
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