Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase
Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson KK, Talalay P
PloS one · 120 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Sin resultado de salud
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Organización sin fines de lucro
- Lewis B. and Dorothy Cullman Foundation
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-11-02 · PLoS One · vol. 10 · número 11 · pág. e0140963
- Editorial
- Public Library of Science
- Citado
- 176 citas · más que el 97% de estudios similares · 5.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Curcumin's Biomedical Applications · Free Radicals and Antioxidants
- Palabras clave
- Glucoraphanin, Sulforaphane, Myrosinase, Glucosinolate, Bioavailability, Chemistry, Isothiocyanate, Food science, Brassica, Biochemistry, Pharmacology, Botany, Medicine, Biology
- MeSH
- humans, brassica, seeds, oximes, imidoesters, isothiocyanates, sulfoxides, glycoside hydrolases, glucosinolates, plant extracts, drug delivery systems, biological availability, dietary supplements, adult, middle aged, female, male, seedlings
6 autores
- Jed W. Fahey🇺🇸 · autor de correspondenciaJohns Hopkins University; Johns Hopkins Medicine
- Walter David Holtzclaw🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Scott L. Wehage🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Kristina L. Wade🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Katherine K. Stephenson🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Paul Talalay🇺🇸Johns Hopkins University; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Glucoraphanin from broccoli and its sprouts and seeds is a water soluble and relatively inert precursor of sulforaphane, the reactive isothiocyanate that potently inhibits neoplastic cellular processes and prevents a number of disease states. Sulforaphane is difficult to deliver in an enriched and stable form for purposes of direct human consumption. We have focused upon evaluating the bioavailability of sulforaphane, either by direct administration of glucoraphanin (a glucosinolate, or β-thioglucoside-N-hydroxysulfate), or by co-administering glucoraphanin and the enzyme myrosinase to catalyze its conversion to sulforaphane at economic, reproducible and sustainable yields. We show that following administration of glucoraphanin in a commercially prepared dietary supplement to a small number of human volunteers, the volunteers had equivalent output of sulforaphane metabolites in their urine to that which they produced when given an equimolar dose of glucoraphanin in a simple boiled and lyophilized extract of broccoli sprouts. Furthermore, when either broccoli sprouts or seeds are administered directly to subjects without prior extraction and consequent inactivation of endogenous myrosinase, regardless of the delivery matrix or dose, the sulforaphane in those preparations is 3- to 4-fold more bioavailable than sulforaphane from glucoraphanin delivered without active plant myrosinase. These data expand upon earlier reports of inter- and intra-individual variability, when glucoraphanin was delivered in either teas, juices, or gelatin capsules, and they confirm that a variety of delivery matrices may be equally suitable for glucoraphanin supplementation (e.g. fruit juices, water, or various types of capsules and tablets).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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