Association between Dietary Magnesium Intake and Hyperuricemia
Wang YL, Zeng C, Wei J, Yang T, Li H, Deng ZH, Yang Y, Zhang Y, Ding X, Xie DX, Yang TB, Lei GH
PloS one · 13 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Development and Reform Commission of Hunan Province
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Ministry of Education of the People's Republic of China
- Universidad u hospital
- Central South University
- Gobierno
- Hunan Provincial Innovation Foundation for Postgraduate
- Gobierno
- Fundamental Research Funds for the Central Universities
- Subvenciones
- National Natural Science Foundation of China (No. 81201420, 81272034); National Natural Science Foundation of China (No. 81201420); Hunan Provincial Innovation Foundation for Postgraduate (81472130); Development and Reform Commission of Hunan Province (81472130); Development and Reform Commission of Hunan Province (81272034); National Natural Science Foundation of China (81201420); Central South University (81472130); Ministry of Education of the People's Republic of China (20120162110036); National Natural Science Foundation of China (81272034); Central South University (81272034); National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130); National Natural Science Foundation of China (14JJ3032); Central South University (14JJ3032); Development and Reform Commission of Hunan Province (14JJ3032); Hunan Provincial Innovation Foundation for Postgraduate (CX2014A005); Hunan Provincial Innovation Foundation for Postgraduate (14JJ3032); Hunan Provincial Innovation Foundation for Postgraduate (81272034); National Natural Science Foundation of China (2013SK2018); National Natural Science Foundation of China (81201420, 81272034, 81472130); National Natural Science Foundation of China (81472130)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-11-04 · PLoS One · vol. 10 · número 11 · pág. e0141079
- Editorial
- Public Library of Science
- Citado
- 23 citas · más que el 81% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gout, Hyperuricemia, Uric Acid · Magnesium in Health and Disease · Diet, Metabolism, and Disease
- Palabras clave
- Hyperuricemia, Magnesium, Medicine, Association (psychology), Endocrinology, Internal medicine, Physiology, Chemistry, Uric acid, Psychology
- MeSH
- humans, hyperuricemia, magnesium, cross-sectional studies, sex characteristics, dietary supplements, aged, middle aged, female, male
12 autores
- Yilun Wang🇨🇳Central South University; Xiangya Hospital Central South University
- Chao Zeng🇨🇳Central South University; Xiangya Hospital Central South University
- Jie Wei🇨🇳Central South University
- Tuo Yang🇨🇳Central South University; Xiangya Hospital Central South University
- Hui Li🇨🇳Central South University; Xiangya Hospital Central South University
- Zhenhan Deng🇨🇳Central South University; Xiangya Hospital Central South University
- Ye Yang🇨🇳Central South University; Xiangya Hospital Central South University
- Yi Zhang🇨🇳Central South University; Xiangya Hospital Central South University
- Xiang Ding🇨🇳Central South University; Xiangya Hospital Central South University
- Dongxing Xie🇨🇳Central South University; Xiangya Hospital Central South University
- Tubao Yang🇨🇳Central South University; Xiangya Hospital Central South University
- Guanghua Lei🇨🇳 · autor de correspondenciaCentral South University; Xiangya Hospital Central South University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the cross-sectional associations between dietary magnesium (Mg) intake and hyperuricemia (HU).
Methods
5168 subjects were included in this study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Hyperuricemia (HU) was defined as uric acid ≥ 416 μmol/L for male population and ≥ 360 μmol/L for female. A multivariable logistic analysis model was applied to test the associations after adjusting a number of potential confounding factors.
Results
The relative odds of the overall prevalence of HU were decreased by 0.57 times in the fourth quintile of Mg intake (OR 0.57, 95% CI 0.35-0.94) and 0.55 times in the fifth quintile (OR 0.55, 95% CI 0.30-1.01) comparing with the lowest quintile, and P for trend was 0.091. The results of multivariable linear regression also suggested a significant inverse association between serum uric acid and Mg intake (β = -0.028, P = 0.022). For male, the relative odds of HU were decreased by 0.62 times in the third quintile of Mg intake (OR 0.62, 95% CI 0.40-0.97), 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.23-0.72) and 0.35 times in the fifth quintile (OR 0.35, 95% CI 0.17-0.71) comparing with the lowest quintile, and P for trend was 0.006. Multivariable adjusted inverse association was also existed between serum uric acid and Mg intake in male population (β = -0.061, P = 0.002). However, no significant association was observed between dietary Mg intake and HU for female.
Conclusions
The findings of this cross-sectional study indicated that dietary Mg intake is inversely associated with HU, independent of some major confounding factors. In addition, this association remains valid for the male subgroup, but not for the female subgroup.
Level of evidence
LevelIII, cross-sectional study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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