Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract
Khalil MI, Ahmmed I, Ahmed R, Tanvir EM, Afroz R, Paul S, Gan SH, Alam N
BioMed research international · 75 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-01-01 · Biomed Res Int · vol. 2015 · págs. 1–10
- Editorial
- Hindawi Publishing Corporation
- Citado
- 110 citas · más que el 99% de estudios similares · 19.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Cardiac Ischemia and Reperfusion · Medicinal Plants and Neuroprotection
- Palabras clave
- Withania somnifera, Lipid peroxidation, Glutathione peroxidase, Superoxide dismutase, Antioxidant, Glutathione reductase, Oxidative stress, Chemistry, Glutathione, Pharmacology, Cardiac marker, Biochemistry, Internal medicine, Enzyme, Endocrinology, Troponin, Medicine, Myocardial infarction, Pathology
- MeSH
- animals, humans, rats, withania, plant leaves, myocardial infarction, isoproterenol, glutathione peroxidase, superoxide dismutase, lipids, troponin i, plant extracts, antioxidants, lipid peroxidation, oxidative stress, biomarkers
8 autores
- Md. Ibrahim Khalil🇲🇾🇧🇩Universiti Sains Malaysia; Jahangirnagar University
- Istiyak Ahmmed🇧🇩Jahangirnagar University
- Romana Ahmed🇧🇩Jahangirnagar University
- E. M. Tanvir🇧🇩Jahangirnagar University
- Rizwana Afroz🇧🇩Jahangirnagar University
- Sudip Paul🇧🇩Jahangirnagar University
- Siew Hua Gan🇲🇾Universiti Sains Malaysia
- Nadia Alam🇲🇾 · autor de correspondenciaUniversiti Sains Malaysia
Resumen
El texto original del estudio, en el idioma en que se publicó.
We investigated the protective role of Withania somnifera leaf extract (WSLEt) on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg body weight (b.w.)) administered to rats for two consecutive days caused a significant increase in cardiac troponin I (cTnI) levels and serum lipid profiles, as well as the activities of some marker enzymes. In addition to these diagnostic markers, there were increased levels of lipid peroxidation (LPO) and decreased activities of enzymatic antioxidants (superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRx), and glutathione-S-transferase (GST)) in the myocardium. However, oral pretreatment (100 mg/kg b.w.) with WSLEt for 4 weeks elicited a significant cardioprotective activity by lowering the levels of cTnI, lipid profiles, and marker enzymes. The levels of LPO products were also significantly decreased. Elevated activities of antioxidant enzymes were also observed in rats pretreated with WSLEt. As further confirmed histopathologically, our findings strongly suggest that the cardioprotective effect of WSLEt on myocardium experiencing ISO-induced oxidative damage may be due to an augmentation of the endogenous antioxidant system and an inhibition of LPO in the myocardial membrane. We conclude that WSLEt confers some protection against oxidative damage in ISO-induced MI in rats.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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