Sex difference in liver-related mortality and transplantation associated with dietary cholesterol in chronic hepatitis C virus infection
Yu L, Morishima C, Ioannou GN
The British journal of nutrition · 1 cita
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Veterans Affairs
- Gobierno
- Office of Research and Development
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
Según 3 financiadores declarados.
Publicación
- Publicado
- 2015-11-06 · Br J Nutr · vol. 115 · número 2 · págs. 193–201
- Editorial
- Cambridge University Press
- Citado
- 3 citas · más que el 51% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Hepatitis C virus research · Liver Disease Diagnosis and Treatment · Liver Disease and Transplantation
- Palabras clave
- Liver transplantation, Cholesterol, Virus, Transplantation, Internal medicine, Medicine, Virology, Chronic hepatitis, Biology, Gastroenterology
- MeSH
- humans, hepatitis c, chronic, liver cirrhosis, cholesterol, dietary, antiviral agents, liver transplantation, risk factors, retrospective studies, cohort studies, sex factors, energy intake, middle aged, female, male
3 autores
- Lei Yu🇺🇸 · autor de correspondenciaUniversity of Washington
- Chihiro Morishima🇺🇸University of Washington; University of Washington Applied Physics Laboratory
- George N. Ioannou🇺🇸University of Washington; VA Puget Sound Health Care System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary cholesterol induces hepatic inflammation and fibrosis in animals. We aimed to determine whether dietary cholesterol affects liver-related mortality in hepatitis C virus (HCV)-infected patients. We performed a retrospective cohort study using extended follow-up data from the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial. The study included HCV patients with advanced fibrosis and compensated cirrhosis. The analysis included 657 patients who completed two FFQ. We assessed whether cholesterol intake, measured in mg/4184 kJ (mg/1000 kcal) of energy intake, was associated with liver-related death or transplantation. In 4·7 (sd 1·6) years, the incidence of liver-related death (n 46) or transplantation (n 52) was 31·8/1000 person-years. The relationship between cholesterol intake and liver-related death or transplantation was significantly different between men and women (test for interaction, P value=0·01). Each higher quartile of cholesterol intake was associated with an increased risk for liver-related death or transplantation in women (adjusted hazard ratio (AHR) 1·83; 95 % CI 1·12, 2·99; P trend=0·02), but not in men (AHR 0·96; 95 % CI 0·76, 1·22; P trend=0·73). Compared with women whose cholesterol intake was within the recommended guidelines (300 mg/d with a 8368 kJ (2000 kcal) diet), women who consumed more cholesterol had significantly increased risk for liver-related death or transplantation (AHR 4·04; 95 % CI 1·42, 11·5). High dietary cholesterol was associated with an increased risk for liver-related death and transplantation in HCV-infected women with advanced fibrosis or compensated cirrhosis. Future studies should assess whether reducing cholesterol intake, among women who consume an excessive amount, can decrease HCV-related mortality.
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