Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study)
Cooke A, Cork MJ, Victor S, Campbell M, Danby S, Chittock J, Lavender T
Acta dermato-venereologica · 42 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (DRF-2012-05-160)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2015-11-09 · Acta Derm Venereol · vol. 96 · número 3 · págs. 323–330
- Editorial
- Soc for Publication of Acta Dermato-Venereologica
- Citado
- 73 citas · más que el 99% de estudios similares · 12.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Neonatal skin health care · Dermatology and Skin Diseases · Advancements in Transdermal Drug Delivery
- Palabras clave
- Medicine, Transepidermal water loss, Sunflower oil, Randomized controlled trial, Atopic dermatitis, Dry skin, Erythema, Stratum corneum, Clinical trial, Massage, Dermatology, Surgery, Internal medicine, Pathology
- MeSH
- skin, humans, erythema, plant oils, emollients, treatment outcome, massage, administration, cutaneous, pilot projects, water loss, insensible, hydrogen-ion concentration, time factors, infant, newborn, england, medication adherence, olive oil, sunflower oil
7 autores
- Alison Cooke🇬🇧 · autor de correspondenciaUniversity of Manchester
- Michael J. Cork
- Suresh Victor🇬🇧 · autor de correspondenciaUniversity of Manchester
- Malcolm Campbell
- Simon G. Danby🇬🇧 · autor de correspondenciaUniversity of Manchester
- John Chittock
- Tina Lavender
Resumen
El texto original del estudio, en el idioma en que se publicó.
Topical oils on baby skin may contribute to development of childhood atopic eczema. A pilot, assessor-blinded, randomized controlled trial assessed feasibility of a definitive trial investigating their impact in neonates. One-hundred and fifteen healthy, full-term neonates were randomly assigned to olive oil, sunflower oil or no oil, twice daily for 4 weeks, stratified by family history of atopic eczema. We measured spectral profile of lipid lamellae, trans-epidermal water loss (TEWL), stratum corneum hydration and pH and recorded clinical observations, at baseline, and 4 weeks post-birth. Recruitment was challenging (recruitment 11.1%; retention 80%), protocol adherence reasonable (79-100%). Both oil groups had significantly improved hydration but significantly less improvement in lipid lamellae structure compared to the no oil group. There were no significant differences in TEWL, pH or erythema/skin scores. The study was not powered for clinical significance, but until further research is conducted, caution should be exercised when recommending oils for neonatal skin.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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