Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study
Dibaba D, Xun P, Yokota K, White E, He K
British journal of cancer · 28 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Office of Dietary Supplements
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (P30 CA 015704); National Cancer Institute (K05-CA154337); National Cancer Institute (R03 CA139261)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-11-10 · Br J Cancer · vol. 113 · número 11 · págs. 1615–1621
- Editorial
- Springer Nature
- Citado
- 39 citas · más que el 80% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-SA
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Pancreatitis Pathology and Treatment
- Palabras clave
- Pancreatic cancer, Incidence (geometry), Medicine, Internal medicine, Cancer, Endocrinology, Physiology, Gastroenterology
- MeSH
- humans, pancreatic neoplasms, magnesium, incidence, proportional hazards models, longitudinal studies, prospective studies, eating, aged, middle aged, washington, female, male, recommended dietary allowances
5 autores
- Daniel Tefera Dibaba🇺🇸Indiana University Bloomington
- Pengcheng Xun🇺🇸Indiana University Bloomington
- Kuninobu Yokota🇯🇵Jikei University School of Medicine
- Emily D. White🇺🇸University of Washington; Fred Hutch Cancer Center
- Ka He🇺🇸 · autor de correspondenciaIndiana University Bloomington
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Studies document that magnesium is inversely associated with the risk of diabetes, which is a risk factor of pancreatic cancer. However, studies on the direct association of magnesium with pancreatic cancer are few and findings are inconclusive. In this study, we aimed to investigate the longitudinal association between magnesium intake and pancreatic cancer incidence in a large prospective cohort study.
Method
A cohort of 66,806 men and women aged 50-76 years at baseline who participated in the VITamins And Lifestyle (VITAL) study was followed from 2000 to 2008. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of pancreatic cancer incidence by magnesium intake categories.
Result
During an average of 6.8-year follow-up, 151 participants developed pancreatic cancer. Compared with those who met the recommended dietary allowance (RDA) for magnesium intake, the multivariable-adjusted HRs (95% CIs) for pancreatic cancer were 1.42 (0.91, 2.21) for those with magnesium intake in the range of 75-99% RDA and 1.76 (1.04, 2.96) for those with magnesium intake <75% RDA. Every 100 mg per day decrement in magnesium intake was associated with a 24% increase in the incidence of pancreatic cancer (HR: 1.24; 95% CI: 1.02, 1.50; P(trend)=0.03). The observed inverse associations appeared not to be appreciably modified by age, gender, body mass index, and non-steroidal anti-inflammatory drug use but appeared to be limited to those taking magnesium supplementation (from multivitamins or individual supplement).
Conclusions
Findings from this prospective cohort study indicate that magnesium intake may be beneficial in terms of primary prevention of pancreatic cancer.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-SA).
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