Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells following Finnish Sauna: A Pilot Study
Donndorf P, Lube L, Lux C, Skorska A, Steinhoff G, Kraft K
Forschende Komplementarmedizin (2006) · 4 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-01-01 · Forsch Komplementmed · vol. 22 · número 4 · págs. 246–250
- Editorial
- Karger Publishers
- Citado
- 7 citas · más que el 77% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 17 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thermoregulation and physiological responses · Skin Protection and Aging · Hair Growth and Disorders
- Palabras clave
- Medicine, CD34, Progenitor cell, Bone marrow, Peripheral blood mononuclear cell, Endothelial progenitor cell, Andrology, Stem cell, Immunology, Internal medicine, Biology, In vitro, Biochemistry
- MeSH
- humans, antigens, cd, steam bath, flow cytometry, cell movement, adult, male, hemodynamics, young adult, endothelial progenitor cells
6 autores
- Peter Donndorf🇩🇪University of Rostock
- Luisa Lube🇩🇪University of Rostock
- Cornelia Aquilina Lux🇩🇪University of Rostock
- Anna Skorska🇩🇪University of Rostock
- Gustav Steinhoff🇩🇪University of Rostock
- Karin Kraft🇩🇪University of Rostock
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Sauna bathing is claimed to provide benefits for patients suffering from cardiovascular diseases. The current study aims at analyzing the induction of potential regenerative processes by quantifying the mobilization of bone marrow-derived stem cells into the peripheral blood of healthy adults following Finnish sauna.
Materials and methods
Twenty healthy unbiased male volunteers (20-30 years old) were exposed to a Finnish sauna bath (3 × 10 min, 90°C). Venous blood samples were drawn before (baseline), immediately, and 6 h as well as 24 h after the sauna bath. Blood analysis included isolation of mononuclear cells, cell staining with mononuclear antibodies, and fluorescence-activated cell sorting (FACS). For baseline and 24 h post-sauna samples colony-forming unit-Hill assays were applied to quantify endothelial progenitor cells (EPC).
Results
Flow cytometry revealed an upregulation of circulating CD45+/CD309+ progenitor cells immediately after the sauna bath, however without reaching statistical significance. Circulating cell numbers of the CD45+CD34+, CD45+CD34+CD133+, and CD45+CD34+CD117+ populations did not show clear enhancements following sauna. EPC colony formation tended to be enhanced after sauna as compared to baseline values.
Conclusion
Peripheral EPC numbers exhibited a moderate increase following Finnish sauna in a cohort of healthy young men. Furthermore, sauna bathing tended to increase EPC colony-forming capacity. These rather weak responses to thermotherapy might indicate a ceiling effect. In individuals exhibiting cardiovascular risk factors the effects may be more pronounced.
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