Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study
Velmurugan S, Gan JM, Rathod KS, Khambata RS, Ghosh SM, Hartley A, Van Eijl S, Sagi-Kiss V, Chowdhury TA, Curtis M, Kuhnle GG, Wade WG, Ahluwalia A
The American journal of clinical nutrition · 231 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- British Heart Foundation
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Gobierno
- Medical Research Council 4-y Master of Research/PhD
- Gobierno
- National Institute for Health Research (NIHR)
- Organización sin fines de lucro
- British Heart Foundation Clinical PhD Fellowship
- Organización sin fines de lucro
- British Heart Foundation Project Grant
- Subvenciones
- British Heart Foundation (FS/11/41/28749); National Institute for Health and Care Research (DRF-2014-07-008)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-11-25 · Am J Clin Nutr · vol. 103 · número 1 · págs. 25–38
- Editorial
- Elsevier BV
- Citado
- 290 citas · más que el 99% de estudios similares · 9.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 69 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Dental Erosion and Treatment · Dye analysis and toxicity
- Palabras clave
- Placebo, Nitrate, Medicine, Internal medicine, Pulse wave velocity, Clinical endpoint, Adverse effect, Randomized controlled trial, Blood pressure, Chemistry, Pathology
- MeSH
- mouth mucosa, blood platelets, monocytes, saliva, humans, bacteria, beta vulgaris, vegetables, hypercholesterolemia, nitrates, nitrites, p-selectin, diet, double-blind method, vasodilation, adult, middle aged, female, male, atherosclerosis
13 autores
- Shanti Velmurugan🇬🇧National Institute for Health and Care Research; William Harvey Research Institute
- Jasmine Ming Gan🇬🇧William Harvey Research Institute
- Krishnaraj Sinhji Rathod🇬🇧National Institute for Health and Care Research; William Harvey Research Institute
- Rayomand S. Khambata🇬🇧National Institute for Health and Care Research; William Harvey Research Institute
- Suborno M. Ghosh🇬🇧National Institute for Health and Care Research; William Harvey Research Institute
- Amy Hartley🇬🇧National Institute for Health and Care Research; William Harvey Research Institute
- Sven van Eijl🇬🇧National Institute for Health and Care Research; William Harvey Research Institute
- Virág Sági‐Kiss🇬🇧University of Reading
- Tahseen Ahmad Chowdhury🇬🇧National Health Service; Barts Health NHS Trust; Royal London Hospital
- Mike Curtis🇲🇲University of Dental Medicine
- Gunter GC Kuhnle🇬🇧University of Reading
- William G. Wade🇬🇧Queen Mary University of London; Blizard Institute
- Amrita Ahluwalia🇬🇧 · autor de correspondenciaNational Institute for Health and Care Research; William Harvey Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The beneficial cardiovascular effects of vegetables may be underpinned by their high inorganic nitrate content.
Objective
We sought to examine the effects of a 6-wk once-daily intake of dietary nitrate (nitrate-rich beetroot juice) compared with placebo intake (nitrate-depleted beetroot juice) on vascular and platelet function in untreated hypercholesterolemics.
Design
A total of 69 subjects were recruited in this randomized, double-blind, placebo-controlled parallel study. The primary endpoint was the change in vascular function determined with the use of ultrasound flow-mediated dilatation (FMD).
Results
Baseline characteristics were similar between the groups, with primary outcome data available for 67 patients. Dietary nitrate resulted in an absolute increase in the FMD response of 1.1% (an ∼24% improvement from baseline) with a worsening of 0.3% in the placebo group (P 1% of this change, with the proportions of Rothia mucilaginosa trending to increase and Neisseria flavescens (P < 0.01) increased after nitrate treatment relative to after placebo treatment.
Conclusions
Sustained dietary nitrate ingestion improves vascular function in hypercholesterolemic patients. These changes are associated with alterations in the oral microbiome and, in particular, nitrate-reducing genera. Our findings provide additional support for the assessment of the potential of dietary nitrate as a preventative strategy against atherogenesis in larger cohorts. This trial was registered at clinicaltrials.gov as NCT01493752.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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