Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis
Song P, Wu L, Guan W
Nutrients · 193 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81372364)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-12-01 · Nutrients · vol. 7 · número 12 · págs. 9872–9895
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 354 citas · más que el 95% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Helicobacter pylori-related gastroenterology studies · Diet, Metabolism, and Disease · Esophageal and GI Pathology
- Palabras clave
- Meta-analysis, Medicine, Relative risk, Confidence interval, Cancer, Internal medicine, Cohort study, Stomach cancer, Prospective cohort study, Gastroenterology
- MeSH
- humans, stomach neoplasms, nitrates, nitrites, nitrosamines, diet, meat
3 autores
- Peng Kun Song🇨🇳Nanjing Drum Tower Hospital
- Lei Wu🇨🇳Jiangsu Province Hospital; Nanjing Medical University
- Wenxian Guan🇨🇳 · autor de correspondenciaNanjing Drum Tower Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
The potential associations between dietary consumption of nitrates, nitrites, and nitrosamines and gastric cancer risk have been investigated by several studies, but yielded inconclusive results. We conducted a meta-analysis to provide a quantitative assessment of their relationships. Relevant articles were identified by a systematic literature searching of PubMed and Embase databases prior to August 2015. Random-effects models were employed to pool the relative risks. A total of 22 articles consisting of 49 studies-19 studies for nitrates, 19 studies for nitrites, and 11 studies for N-nitrosodimethylamine (NDMA)-were included. The summary relative risk of stomach cancer for the highest categories, compared with the lowest, was 0.80 (95% confidence interval (CI), 0.69-0.93) for dietary nitrates intake, 1.31 (95% CI, 1.13-1.52) for nitrites, and 1.34 (95% CI, 1.02-1.76) for NDMA (p for heterogeneity was 0.015, 0.013 and <0.001, respectively). The study type was found as the main source of heterogeneity for nitrates and nitrites. The heterogeneity for NDMA could not be eliminated completely through stratified analysis. Although significant associations were all observed in case-control studies, the cohort studies still showed a slight trend. The dose-response analysis indicated similar results as well. High nitrates intake was associated with a weak but statistically significant reduced risk of gastric cancer. Whereas increased consumption of nitrites and NDMA seemed to be risk factors for cancer. Due to the lack of uniformity for exposure assessment across studies, further prospective researches are warranted to verify these findings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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