Formulation and clinical evaluation of topical dosage forms of Indian Penny Wort, walnut and turmeric in eczema
Khiljee S, Rehman N, Khiljee T, Loebenberg R, Ahmad RS
Pakistan journal of pharmaceutical sciences · 10 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-11-01 · Pak J Pharm Sci · vol. 28 · número 6 · págs. 2001–7
- Editorial
- National Institutes of Health
- Citado
- 18 citas · más que el 63% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Advancements in Transdermal Drug Delivery · Dermatology and Skin Diseases · Contact Dermatitis and Allergies
- Palabras clave
- atopic dermatitis, Juglans regia, turmeric, microemulsions, topical gel, ointments, formulation stability, erythema, edema, lichenification, scaling, pruritus, herbal medicine
- MeSH
- humans, centella, juglans, curcuma, plant leaves, plant stems, rhizome, plants, medicinal, eczema, plant extracts, dermatologic agents, emulsions, gels, ointments, treatment outcome, phytotherapy, administration, cutaneous, severity of illness index, chi-square distribution, double-blind method, chemistry, pharmaceutical, time factors, pakistan, female, male
5 autores
- Sonia Khiljee🇨🇦🇵🇰University of Alberta; Islamia University of Bahawalpur; University of Veterinary and Animal Sciences
- Nisar-ur Rehman🇵🇰COMSATS University Islamabad; Islamia University of Bahawalpur
- Tanzila Khiljee🇵🇰Islamia University of Bahawalpur; University of Veterinary and Animal Sciences
- Raimar Löebenberg🇨🇦University of Alberta
- Rao Saeed Ahmad🇵🇰Islamia University of Bahawalpur
Resumen
El texto original del estudio, en el idioma en que se publicó.
Eczema is characterized by itching, lichenification, scaling, oedema and erythema. Current management strategies include corticosteroids, which are limited due to side effects. Many herbal remedies are used traditionally but unfortunately have not been validated in controlled clinical trials. Three popular traditional treatments of eczema include Indian pennywort, Walnut and Turmeric. In this study three topical formulations (micro emulsion, gel and ointment) were prepared from extracts of Indian pennywort, Walnut and Turmeric. These formulations were monitored for stability for a period of three months. Controlled clinical trials were conducted on 360 eczema patients. Clinical parameters observed were degree of erythema, oedema, scaling, itching and lichenification. Effects of each formulation on these clinical parameters were compared with placebo formulations. Micro emulsion formulations in all cases proved to be more effective in reducing semi quantitative scores of erythema and oedema. Itching was relieved more by gel formulation. The ointment showed more efficacy towards scaling and lichenification. Comparison of the effects of placebo and the specific formulations was performed by chi-square statistics and found to be highly significant. In summary it is concluded that all the formulations could be used as promising source for treatment of eczema.
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