Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials
Best KP, Gold M, Kennedy D, Martin J, Makrides M
The American journal of clinical nutrition · 107 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Office of Dietary Supplements
- Gobierno
- National Institutes of Health
- Gobierno
- NIH
- Subvenciones
- Office of Dietary Supplements (P20 HL113452); National Institutes of Health (R01HL103866)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2015-12-17 · Am J Clin Nutr · vol. 103 · número 1 · págs. 128–143
- Editorial
- Elsevier BV
- Citado
- 177 citas · más que el 91% de estudios similares · 2.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Food Allergy and Anaphylaxis Research · Asthma and respiratory diseases
- Palabras clave
- n-3 long-chain polyunsaturated fatty acids, prenatal supplementation, IgE-mediated allergic diseases, atopic dermatitis, rhinoconjunctivitis, asthma, food sensitization, skin prick test, fish consumption
- MeSH
- humans, dermatitis, atopic, hypersensitivity, food hypersensitivity, fatty acids, omega-3, diet, pregnancy, dietary supplements, female, prenatal nutritional physiological phenomena
5 autores
- Karen P Best🇦🇺 · autor de correspondenciaWomen's & Children's Health Research Institute; South Australian Health and Medical Research Institute; The University of Adelaide
- Michael Gold🇦🇺Women's and Children's Health Network
- Declan Kennedy🇦🇺Women's and Children's Hospital; Women's and Children's Health Network; The University of Adelaide
- James A. Martin🇦🇺Women's and Children's Hospital; Women's and Children's Health Network; The University of Adelaide
- Maria Makrides🇦🇺Women's & Children's Health Research Institute; South Australian Health and Medical Research Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There is some evidence that increased maternal intake of omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may reduce the incidence of immunoglobulin E (IgE)-mediated allergic disease.
Objective
We aimed to evaluate prenatal n-3 LC-PUFA dietary exposure in observational studies and n-3 LC-PUFA supplementation in randomized controlled trials (RCTs) on outcomes of IgE-mediated allergic disease.
Design
We conducted searches of the Cochrane Central Register of Controlled Trials, PubMed, Ovid MEDLINE, EMBASE, CINAHL, SCOPUS, and Web of Science to 30 July 2015. We included prospective cohort studies that showed an association between maternal fish or n-3 LC-PUFA intake during pregnancy and RCTs with a prenatal intervention to modify maternal n-3 LC-PUFA intake and outcomes of allergic disease (eczema, rhino-conjunctivitis, asthma) or sensitization in the offspring.
Results
A total of 13 publications from 10 prospective cohort studies and 7 publications representing 5 unique RCTs were included. Three RCTs were combined in a meta-analysis for selected outcomes. Nine of 13 observational study publications and 5 of 7 publications from RCTs found a protective association between increased prenatal n-3 LC-PUFA or fish intake and incidence of allergic disease symptoms in the child. Meta-analysis was limited because of the heterogeneity of the RCTs. Pooled results showed a significant reduction in the incidence of "atopic eczema," "any positive SPT [skin-prick test]," "sensitization to egg," and "sensitization to any food" in the first 12 mo of life [RRs (95% CIs): 0.53 (0.35, 0.81), P = 0.004; 0.68 (0.52-0.89), P = 0.006; 0.55 (0.39-0.76), P = 0.0004; and 0.59 (0.46, 0.76), P < 0.0001, respectively].
Conclusions
Our systematic review and meta-analysis was suggestive of benefits of increased n-3 LC-PUFAs in the maternal diet and outcomes of childhood allergic disease. However, due to the inconsistency in results, the hypothesis linking maternal n-3 LC-PUFA intake to childhood allergic disease cannot unequivocally be confirmed or rejected.
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