Omega-3 Fatty Acid Supplementation for 12 Weeks Increases Resting and Exercise Metabolic Rate in Healthy Community-Dwelling Older Females
Logan SL, Spriet LL
PloS one · 110 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Guelph
- Gobierno
- Natural Sciences and Engineering Research Council of Canada
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-12-17 · PLoS One · vol. 10 · número 12 · pág. e0144828
- Editorial
- Public Library of Science
- Citado
- 154 citas · más que el 98% de estudios similares · 7.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Muscle metabolism and nutrition · Nutrition and Health in Aging
- Palabras clave
- omega-3 fatty acids, fish oil supplementation, EPA, docosahexaenoic acid, resting metabolic rate, substrate oxidation, fat oxidation, energy expenditure, older women, aging, body composition, lean body mass, functional capacity, blood pressure, heart rate, triglycerides, insulin, C-reactive protein, olive oil placebo
- MeSH
- humans, fatty acids, omega-3, basal metabolism, exercise, single-blind method, blood pressure, dietary supplements, aged, middle aged, female, independent living
2 autores
- Samantha L. Logan🇨🇦 · autor de correspondenciaUniversity of Guelph
- Lawrence L. Spriet🇨🇦University of Guelph
Resumen
El texto original del estudio, en el idioma en que se publicó.
Critical among the changes that occur with aging are decreases in muscle mass and metabolic rate and an increase in fat mass. These changes may predispose older adults to chronic disease and functional impairment; ultimately resulting in a decrease in the quality of life. Research has suggested that long chain omega-3 fatty acids, found predominantly in fatty fish, may assist in reducing these changes. The objective of this study was to evaluate the effect of fish oil (FO) supplementation in a cohort of healthy, community-dwelling older females on 1) metabolic rate and substrate oxidation at rest and during exercise; 2) resting blood pressure and resting and exercise heart rates; 3) body composition; 4) strength and physical function, and; 5) blood measures of insulin, glucose, c-reactive protein, and triglycerides. Twenty-four females (66 ± 1 yr) were recruited and randomly assigned to receive either 3g/d of EPA and DHA or a placebo (PL, olive oil) for 12 wk. Exercise measurements were taken before and after 12 wk of supplementation and resting metabolic measures were made before and at 6 and 12 wk of supplementation. The results demonstrated that FO supplementation significantly increased resting metabolic rate by 14%, energy expenditure during exercise by 10%, and the rate of fat oxidation during rest by 19% and during exercise by 27%. In addition, FO consumption lowered triglyceride levels by 29% and increased lean mass by 4% and functional capacity by 7%, while no changes occurred in the PL group. In conclusion, FO may be a strategy to improve age-related physical and metabolic changes in healthy older females. Trial registration: ClinicalTrials.gov NCT01734538.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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