A randomized controlled study of the efficacy of six-month supplementation with concentrated fish oil rich in omega-3 polyunsaturated fatty acids in first episode schizophrenia
Pawełczyk T, Grancow-Grabka M, Kotlicka-Antczak M, Trafalska E, Pawełczyk A
Journal of psychiatric research · 86 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-11-25 · J Psychiatr Res · vol. 73 · págs. 34–44
- Editorial
- Elsevier BV
- Citado
- 117 citas · más que el 95% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 74 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Schizophrenia research and treatment · Tryptophan and brain disorders
- Palabras clave
- omega-3 polyunsaturated fatty acids, fish oil supplementation, first-episode schizophrenia, adjunctive therapy, symptom severity, depressive symptoms, functioning, long-term intervention, olive oil placebo, eicosapentaenoic acid
- MeSH
- humans, fatty acids, omega-3, eicosapentaenoic acid, fish oils, antipsychotic agents, treatment outcome, follow-up studies, double-blind method, reproducibility of results, schizophrenia, mental status schedule, age factors, dietary supplements, adolescent, adult, female, male, young adult, outcome assessment, health care
5 autores
- Tomasz Pawełczyk🇵🇱 · autor de correspondenciaMedical University of Lodz
- Marta Grancow-Grabka🇵🇱Medical University of Lodz
- Magdalena Kotlicka‐Antczak🇵🇱Medical University of Lodz
- Elżbieta Trafalska🇵🇱Medical University of Lodz
- Agnieszka Maria Pawełczyk🇵🇱Medical University of Lodz
Resumen
El texto original del estudio, en el idioma en que se publicó.
Short-term clinical trials of omega-3 polyunsaturated fatty acids (n-3 PUFA) as add-on therapy in patients with schizophrenia revealed mixed results. The majority of these studies used an 8- to 12-week intervention based on ethyl-eicosapentaenoic acid. A randomized placebo-controlled trial was designed to compare the efficacy of 26-week intervention, composed of either 2.2 g/day of n-3 PUFA, or olive oil placebo, with regard to symptom severity in first-episode schizophrenia patients. Seventy-one patients (aged 16-35) were enrolled in the study and randomly assigned to the study arms. The primary outcome measure of the clinical evaluation was schizophrenia symptom severity change measured by the Positive and Negative Syndrome Scale (PANSS). Mixed models repeated measures analysis revealed significant differences between the study arms regarding total PANSS score change favouring n-3 PUFA (p = 0.016; effect size (ES) = 0.29). A fifty-percent improvement in symptom severity was achieved significantly more frequently in the n-3 PUFA group than in the placebo group (69.4 vs 40.0%; p = 0.017). N-3 PUFA intervention was also associated with an improvement in general psychopathology, measured by means of PANSS (p = 0.009; ES = 0.32), depressive symptoms (p = 0.006; ES = 0.34), the level of functioning (p = 0.01; ES = 0.31) and clinical global impression (p = 0.046; ES = 0.29). The findings suggest that 6-month intervention with n-3 PUFA may be a valuable add-on therapy able to decrease the intensity of symptoms and improve the level of functioning in first-episode schizophrenia patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.