Financiado en parte por GlaxoSmithKline, Astellas Pharma
Acute Dietary Nitrate Supplementation and Exercise Performance in COPD: A Double-Blind, Placebo-Controlled, Randomised Controlled Pilot Study
Curtis KJ, O'Brien KA, Tanner RJ, Polkey JI, Minnion M, Feelisch M, Polkey MI, Edwards LM, Hopkinson NS
PloS one · 44 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- GlaxoSmithKline
- Universidad u hospital
- Royal Brompton and Harefield NHS Foundation Trust
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- Imperial College London
- Universidad u hospital
- King's College London
- Empresa
- Astellas Pharma
- Gobierno
- Medical Research Council
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Medical Research Council (MR/J000620/1); Medical Research Council (G1001536)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-12-23 · PLoS One · vol. 10 · número 12 · pág. e0144504
- Editorial
- Public Library of Science
- Citado
- 56 citas · más que el 93% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Chronic Obstructive Pulmonary Disease (COPD) Research · Cardiovascular and exercise physiology · Exercise and Physiological Responses
- Palabras clave
- Placebo, Crossover study, Medicine, Nitrate, Time trial, Dietary Nitrate, COPD, VO2 max, Anesthesia, Internal medicine, Blood pressure, Animal science, Heart rate, Nitrite, Chemistry
- MeSH
- humans, pulmonary disease, chronic obstructive, nitrates, prognosis, exercise therapy, magnetic resonance spectroscopy, follow-up studies, pilot projects, cross-over studies, double-blind method, oxygen consumption, dietary supplements, aged, female, male
9 autores
- Katrina Curtis🇬🇧Royal Brompton & Harefield NHS Foundation Trust; Imperial College London
- Katie A. O’Brien🇬🇧King's College London
- Rebecca Tanner🇬🇧Royal Brompton & Harefield NHS Foundation Trust; Imperial College London
- Juliet I. Polkey🇬🇧Royal Brompton & Harefield NHS Foundation Trust; Imperial College London
- Magdalena Minnion🇬🇧Southampton General Hospital; NIHR Southampton Respiratory Biomedical Research Unit; University of Southampton
- Martin Feelisch🇬🇧Southampton General Hospital; NIHR Southampton Respiratory Biomedical Research Unit; University of Southampton
- Michael Iain Polkey🇬🇧Royal Brompton & Harefield NHS Foundation Trust; Imperial College London
- Lindsay M. Edwards🇬🇧King's College London
- Nicholas S Hopkinson🇬🇧 · autor de correspondenciaRoyal Brompton & Harefield NHS Foundation Trust; Imperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary nitrate supplementation can enhance exercise performance in healthy people, but it is not clear if it is beneficial in COPD. We investigated the hypotheses that acute nitrate dosing would improve exercise performance and reduce the oxygen cost of submaximal exercise in people with COPD.
Methods
We performed a double-blind, placebo-controlled, cross-over single dose study. Subjects were randomised to consume either nitrate-rich beetroot juice (containing 12.9 mmoles nitrate) or placebo (nitrate-depleted beetroot juice) 3 hours prior to endurance cycle ergometry, performed at 70% of maximal workload assessed by a prior incremental exercise test. After a minimum washout period of 7 days the protocol was repeated with the crossover beverage.
Results
21 subjects successfully completed the study (age 68 ± 7 years; BMI 25.2 ± 5.5 kg/m2; FEV1 percentage predicted 50.1 ± 21.6%; peak VO2 18.0 ± 5.9 ml/min/kg). Resting diastolic blood pressure fell significantly with nitrate supplementation compared to placebo (-7 ± 8 mmHg nitrate vs. -1 ± 8 mmHg placebo; p = 0.008). Median endurance time did not differ significantly; nitrate 5.65 (3.90-10.40) minutes vs. placebo 6.40 (4.01-9.67) minutes (p = 0.50). However, isotime oxygen consumption (VO2) was lower following nitrate supplementation (16.6 ± 6.0 ml/min/kg nitrate vs. 17.2 ± 6.0 ml/min/kg placebo; p = 0.043), and consequently nitrate supplementation caused a significant lowering of the amplitude of the VO2-percentage isotime curve.
Conclusions
Acute administration of oral nitrate did not enhance endurance exercise performance; however the observation that beetroot juice caused reduced oxygen consumption at isotime suggests that further investigation of this treatment approach is warranted, perhaps targeting a more hypoxic phenotype.
Trial registration
ISRCTN Registry ISRCTN66099139.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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