Egg consumption and risk of type 2 diabetes: a meta-analysis of prospective studies
Djoussé L, Khawaja OA, Gaziano JM
The American journal of clinical nutrition · 52 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-01-07 · Am J Clin Nutr · vol. 103 · número 2 · págs. 474–480
- Editorial
- Elsevier BV
- Citado
- 83 citas · más que el 92% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins · Diet, Metabolism, and Disease
- Palabras clave
- egg consumption, type 2 diabetes, diabetes risk, dietary protein, dose-response relationship, prospective cohort
- MeSH
- humans, diabetes mellitus, type 2, diet, risk, prospective studies, reproducibility of results, evidence-based medicine, eggs, united states, global health
3 autores
- Luc Djoussé🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- Owais A. Khawaja🇺🇸Mercy St. Vincent Medical Center
- J. Michael Gaziano🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Observational data on the association between egg consumption and risk of type 2 diabetes mellitus (DM) have been inconsistent. Because eggs are a good source of protein and micronutrients and are inexpensive, it is important to clarify their role in the risk of developing DM.
Objective
We conducted a meta-analysis of published prospective cohort studies to evaluate the relation of egg consumption with the risk of DM.
Design
We searched PubMed, Ovid, Cochrane, and Google Scholar (up to October 2015) to retrieve published studies. We used RRs from extreme categories of egg consumption for the main analysis but also evaluated dose response by using cubic splines and generalized least squares regression.
Results
We identified 12 cohorts for a total of 219,979 subjects and 8911 cases of DM. When comparing the highest with the lowest category of egg intake, pooled multivariate RRs of DM were 1.09 (95% CI: 0.99, 1.20) using the fixed-effect model and 1.06 (95% CI: 0.86, 1.30) using the random-effect model. There was evidence for heterogeneity (I(2) = 73.6%, P < 0.001). When stratified by geographic area, there was a 39% higher risk of DM (95% CI: 21%, 60%) comparing highest with lowest egg consumption in US studies (I(2) = 45.4%, P = 0.089) and no elevated risk of DM with egg intake in non-US studies (RR = 0.89; 95% CI: 0.79, 1.02 using the fixed-effect model, P < 0.001 comparing US with non-US studies). In a dose-response assessment using cubic splines, elevated risk of DM was observed in US studies among people consuming ≥3 eggs/wk but not in non-US studies.
Conclusions
Our meta-analysis shows no relation between infrequent egg consumption and DM risk but suggests a modest elevated risk of DM with ≥3 eggs/wk that is restricted to US studies.
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