Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis
Lin J, Liu J, Davies ML, Chen W
PloS one · 109 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-01-11 · PLoS One · vol. 11 · número 1 · pág. e0146351
- Editorial
- Public Library of Science
- Citado
- 172 citas · más que el 100% de estudios similares · 16.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 87 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Rheumatoid Arthritis Research and Therapies · Systemic Lupus Erythematosus Research
- Palabras clave
- rheumatoid arthritis, vitamin D, 25-hydroxyvitamin D, disease activity, DAS28, C-reactive protein, serum vitamin D levels, latitude, developing countries, autoimmune disease
- MeSH
- humans, arthritis, rheumatoid, vitamin d, case-control studies, publication bias
4 autores
- Jin Lin🇨🇳First Affiliated Hospital Zhejiang University; Zhejiang University
- Jian Liu🇨🇳First Affiliated Hospital Zhejiang University; Zhejiang University
- Michael L. Davies🇺🇸Rosalind Franklin University of Medicine and Science
- Weiqian Chen🇨🇳 · autor de correspondenciaFirst Affiliated Hospital Zhejiang University; Zhejiang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The evidence from epidemiological studies concerning the relationship between serum vitamin D concentrations and rheumatoid arthritis (RA) is inconsistent. This meta-analysis is aimed at determining the magnitude of the correlation between this common autoimmune disease and vitamin D, an important nutrient known to dampen adaptive immune responses.
Methods
Through multiple search strategies, relevant literature was identified and evaluated for quality before May 16 2015. Data extracted from eligible studies was synthesized to calculate pooled correlation coefficient (r), mean difference (MD) and odds ratio (OR). The Venice criteria were applied to assess the credibility of the evidence for each statistically significant association.
Results
A total of 24 reports involving 3489 patients were selected for analysis. RA patients had lower vitamin D levels than healthy controls (MD:-16.52 nmol/L, 95% confidence intervals [CI]:-18.85 to -14.19 nmol/L). There existed a negative relationship between serum 25-hydroxyvitamin D (25OHD) level and disease activity index, e.g. 25OHD vs. Disease Activity Score in 28 joints (DAS28): r = -0.13, 95% CI -0.16 to -0.09; 25OHD vs. C-reactive protein: r = -0.12, 95% CI -0.23 to -0.00. Additionally, latitude-stratified subgroup analysis yielded a relatively stronger negative correlation between 25OHD and DAS28 in low-latitude areas. This inverse relationship also appeared more significant in developing countries than in developed countries. No publication bias was detected.
Conclusion
RA patients had lower vitamin D values than healthy controls. There was a negative association between serum vitamin D and RA disease activity. However, more strictly controlled studies are needed to validate these findings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.