Effect of Docosahexaenoic Acid on a Biomarker of Head Trauma in American Football
Oliver JM, Jones MT, Kirk KM, Gable DA, Repshas JT, Johnson TA, Andréasson U, Norgren N, Blennow K, Zetterberg H
Medicine and science in sports and exercise · 73 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-01-13 · Med Sci Sports Exerc · vol. 48 · número 6 · págs. 974–982
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 109 citas · más que el 96% de estudios similares · 5.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Proteoglycans and glycosaminoglycans research · Seaweed-derived Bioactive Compounds
- Palabras clave
- American football, Docosahexaenoic acid, Football, Biomarker, Placebo, Medicine, Athletes, Concussion, Internal medicine, Traumatic brain injury, Poison control, Endocrinology, Injury prevention, Physical therapy, Fatty acid, Polyunsaturated fatty acid, Biology, Pathology, Psychiatry, Biochemistry, Environmental health
- MeSH
- humans, brain concussion, neurofilament proteins, docosahexaenoic acids, double-blind method, football, dietary supplements, biomarkers
10 autores
- Jonathan Michael Oliver🇺🇸🇬🇧🇸🇪Texas Christian University; University College London; University of Gothenburg
- Margaret T. Jones🇬🇧🇸🇪University College London; University of Gothenburg
- K. Michele Kirk🇬🇧🇸🇪University College London; University of Gothenburg
- David A. Gable🇬🇧🇸🇪University College London; University of Gothenburg
- Justin Repshas🇬🇧🇸🇪University College London; University of Gothenburg
- Torie A. Johnson🇬🇧🇸🇪University College London; University of Gothenburg
- Ulf Andréasson🇬🇧🇸🇪University College London; University of Gothenburg
- Niklas Norgren🇬🇧🇸🇪University College London; University of Gothenburg
- Kaj Blennow🇬🇧🇸🇪University College London; University of Gothenburg
- Henrik Zetterberg🇬🇧🇸🇪University College London; University of Gothenburg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
American football athletes are exposed to subconcussive impacts over the course of the season resulting in elevations in serum neurofilament light (NFL), a biomarker of axonal injury. Docosahexaenoic acid (DHA) has been reported to reduce axonal trauma associated with traumatic brain injury in rodent models. However, the optimal dose in American football athletes is unknown. This study examined the effect of differing doses of DHA on serum NFL over the course of a season of American football.
Methods
In a randomized, double-blind, placebo-controlled, parallel design, 81 National Collegiate Athletic Association Division I American football athletes were assigned to ingest either 2, 4, 6 g·d of DHA or placebo. Blood was sampled at specific times over the course of 189 d, coincident with changes in intensity, hours of contact, and likely changes in head impacts. Standardized magnitude-based inference was used to define outcomes.
Results
DHA supplementation increased plasma DHA in a dose-dependent manner (2 g·d: mean difference from baseline; ±90% CL; 2 g·d: 1.3; ±0.6; 4 g·d: 1.6; ±0.7%; 6 g·d: 2.8; ±1.2%). Serum NFL increased to a greater extent in starters (area under the curve, 1995 ± 1383 pg·mL) versus nonstarters (1398 ± 581 pg·mL; P = 0.024). Irrespective of dose, supplemental DHA likely attenuated serum NFL coincident with increases in serum NFL by likely small and moderate magnitude (effect size = 0.4-0.7).
Conclusions
Findings from this study, the first large-scale study examining potential prophylactic use of DHA in American football athletes, include identification of optimal dose of DHA, suggesting a neuroprotective effect of DHA supplementation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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