Effect of dietary nitrate supplementation on metabolic rate during rest and exercise in human: A systematic review and a meta-analysis
Pawlak-Chaouch M, Boissière J, Gamelin FX, Cuvelier G, Berthoin S, Aucouturier J
Nitric oxide : biology and chemistry · 58 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-01-06 · Nitric Oxide · vol. 53 · págs. 65–76
- Editorial
- Elsevier BV
- Citado
- 80 citas · más que el 95% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Nitric Oxide and Endothelin Effects
- Palabras clave
- dietary nitrate, nitrate supplementation, oxygen consumption, metabolic rate, physical activity, resting metabolism, exercise intensity, cardiopulmonary disease, beetroot, exercise tolerance
- MeSH
- humans, nitrates, oxygen, exercise, energy metabolism, rest, dietary supplements, randomized controlled trials as topic
6 autores
- Mehdi Pawlak‐Chaouch🇫🇷Unité de Recherche Pluridisciplinaire Sport, Santé, Société
- Julien Boissière🇫🇷Unité de Recherche Pluridisciplinaire Sport, Santé, Société
- François Xavier Gamelin🇫🇷Unité de Recherche Pluridisciplinaire Sport, Santé, Société
- Grégory Cuvelier🇧🇪Haute École Provinciale de Hainaut Condorcet
- Serge Berthoin🇫🇷Unité de Recherche Pluridisciplinaire Sport, Santé, Société
- Julien Aucouturier🇫🇷 · autor de correspondenciaUnité de Recherche Pluridisciplinaire Sport, Santé, Société
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Recent randomized controlled trials have suggested that dietary nitrate (NO3(-)), found in beetroot and other vegetables, and inorganic NO3(-) salts decrease metabolic rate under resting and exercise conditions.
Objective
Our aim was therefore to determine from a systematic review and meta-analysis whether dietary NO3(-) supplementation significantly reduces metabolic rate, expressed as oxygen uptake (VO2), under resting and exercise conditions in healthy humans and those with cardiorespiratory diseases.
Design
A systematic article search was performed on electronic databases (PubMed, Scopus and Web of Science) from February to March 2015. The inclusion criteria included 1) randomized controlled trials; 2) studies reporting the effect of NO3(-) on VO2 under resting and/or exercise conditions; 3) comparison between dietary NO3(-) supplementation and placebo. Random-effects models were used to calculate the pooled effect size.
Results
Twenty nine randomized placebo-controlled trials were included in the systematic review, and 26 of which were included in the meta-analysis. Dietary NO3(-) supplementation significantly decreases VO2 during submaximal intensity exercise [-0.26 (95% IC: -0.38, -0.15), p < 0.01], but not in the sub-analysis of subjects with chronic diseases [-0.09 (95% IC: -0.50, 0.32), p = 0.67]. When data were separately analyzed by submaximal intensity domains, NO3(-) supplementation reduces VO2 during moderate [-0.29 (95% IC: -0.48,-0.10), p < 0.01] and heavy [-0.33 (95% IC: -0.54,-0.12), p < 0.01] intensity exercise. When the studies with the largest effects were excluded from the meta-analysis, there is a trend for a VO2 decrease under resting condition in dietary NO3(-) supplementation [-0.28 (95% IC: -0.62, 0.05), p = 0.10].
Conclusion
Dietary NO3(-) supplementation decreases VO2 during exercise performed in the moderate and heavy intensity domains in healthy subjects. The present meta-analysis did not show any significant effect of dietary NO3(-) supplementation on metabolic rate in subjects with chronic diseases, despite enhanced exercise tolerance.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.