Effects of omega-3 fatty acids in prevention of early preterm delivery: a systematic review and meta-analysis of randomized studies
Kar S, Wong M, Rogozinska E, Thangaratinam S
European journal of obstetrics, gynecology, and reproductive biology · 72 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2015-11-30 · Eur J Obstet Gynecol Reprod Biol · vol. 198 · págs. 40–46
- Editorial
- Elsevier BV
- Citado
- 110 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Preterm Birth and Chorioamnionitis · Birth, Development, and Health
- Palabras clave
- omega-3 fatty acids, preterm birth, eicosapentaenoic acid, docosahexaenoic acid, preterm birth prevention, gestational age, birth weight, maternal supplementation, very preterm birth, infant mortality risk factors
- MeSH
- humans, premature birth, tocolytic agents, fatty acids, omega-3, pregnancy outcome, pregnancy, dietary supplements, female
4 autores
- Sumit Kar🇬🇧 · autor de correspondenciaBarts Health NHS Trust; Royal London Hospital
- Min Wong🇬🇧Barts Health NHS Trust; Whipps Cross University Hospital
- Ewelina Rogozińska🇬🇧Queen Mary University of London
- Shakila Thangaratinam🇬🇧Queen Mary University of London; Barts Health NHS Trust; Royal London Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Preterm birth continues to be the one of the leading causes of infant deaths worldwide. There is a need for effective, easily available, safe and acceptable interventions to prevent preterm delivery, especially before 34 weeks of gestation. Omega-3 fatty acids such as EPA (eicosapentanoic acid) and DHA (docosahexanoic acid) are available as over the counter nutritional supplements, and are taken by women to improve pregnancy outcomes, without any clear recommendations. We undertook a systematic review to assess the effects of omega-3 fatty acids on early (<34 weeks) and any (<37 weeks) preterm delivery.
Methods
We searched MEDLINE, EMBASE and Cochrane Library from inception to 2014 without any language restrictions. Study selection, quality assessment and data extraction were done by two independent reviewers. Results were summarized as relative risks and 95% confidence intervals for dichotomous outcomes and mean differences for continuous outcomes.
Results
Of the nine included trials (5980 women), six (4193 women) evaluated the effects of omega-3 fatty acids on early preterm delivery. The risk of early preterm delivery was reduced by 58% (RR 0.42; 95% CI 0.27-0.66; I(2)=0%; p=0.0002) and any preterm delivery by 17% (RR 0.83; 95% CI 0.70-0.98; I(2)=0%; p=0.03) with the intervention. There was a significant increase in the mean gestational age by 1.95 weeks (95% CI 0.42-3.48 weeks; I(2)=0.47; p=0.01) and mean birth weight by 122.1g (95% CI 47.4-196.8; I(2)=0.84; p=0.001) in the intervention group compared to the controls. Subgroup analysis showed no significant differences in the effects between the groups according to the risk status, dose and timing of the intervention.
Conclusion
Omega-3 fatty acids are effective in preventing early and any preterm delivery. The intervention is simple and easily available and has the potential to influence population based strategies in the prevention of preterm birth.
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