Serum Levels of 25-Hydroxyvitamin D and Time to Natural Pregnancy
Somigliana E, Paffoni A, Lattuada D, Colciaghi B, Filippi F, La Vecchia I, Tirelli A, Baffero GM, Persico N, Viganò P, Bolis G, Fedele L
Gynecologic and obstetric investigation · 16 citas
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Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-01-01 · Gynecol Obstet Invest · vol. 81 · número 5 · págs. 468–471
- Editorial
- Karger Publishers
- Citado
- 24 citas · más que el 88% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Vitamin D Research Studies · Cancer Risks and Factors · Vitamin C and Antioxidants Research
- Palabras clave
- Medicine, Pregnancy, Vitamin D and neurology, Prospective cohort study, Overweight, Internal medicine, vitamin D deficiency, Vitamin, Endocrinology, Gynecology, Obesity, Biology
- MeSH
- humans, vitamin d, case-control studies, fertility, pregnancy, pregnancy trimester, first, adult, female
12 autores
- Edgardo Somigliana🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Alessio Paffoni🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Debora Lattuada🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Barbara Colciaghi🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Francesca Filippi🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Irene La Vecchia🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Amedea Silvia Tirelli🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Giulia Maria Baffero🇮🇹University of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Nicola Persico🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Paola Viganò🇮🇹San Raffaele University of Rome
- Giorgio Bolis🇮🇹University of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Luigi Fedele🇮🇹University of Milan; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
The aim of this study was to evaluate whether natural fertility is related to serum 25-hydroxyvitamin D (25-OH-vitamin D) levels.
Methods
A nested case-control study was designed from a prospective cohort of pregnant women undergoing first trimester screening for aneuploidies. Cases included women seeking pregnancy for 12-24 months. Controls were the subsequent age-matched women conceiving in less than 1 year. We excluded women aged ≥40 or <18 years, those assuming supplementary products that included vitamin D before or during pregnancy, those with irregular menstrual cycles or known causes of subfertility, those conceiving through assisted reproductive techniques or requiring ovarian stimulation and those who were overweight or obese. A quantitative detection of serum 25-OH-vitamin D and patients' interview were performed.
Results
Seventy-three cases and 73 matched controls were selected. The mean ± SD serum 25-OH-vitamin D was 21.2 ± 6.8 and 19.7 ± 7.3 ng/ml, respectively (p = 0.16). The number (%) of women with serum levels <20 ng/ml (vitamin D insufficiency) was 34 (47%) and 37 (51%), respectively (p = 0.73). The adjusted OR of longer time to pregnancy in women with vitamin D insufficiency was 0.84 (95% CI 0.42-1.66).
Conclusions
Our study does not support a crucial role of 25-OH-vitamin D in natural fertility.
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