Low Serum 25-Hydroxyvitamin D Levels Are Associated with Dry Eye Syndrome
Yoon SY, Bae SH, Shin YJ, Park SG, Hwang SH, Hyon JY, Wee WR
PloS one · 47 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Foundation
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-01-25 · PLoS One · vol. 11 · número 1 · pág. e0147847
- Editorial
- Public Library of Science
- Citado
- 68 citas · más que el 97% de estudios similares · 6.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Ocular Surface and Contact Lens · Vitamin D Research Studies · Dermatology and Skin Diseases
- Palabras clave
- Vitamin D and neurology, Medicine, Internal medicine, Biology
- MeSH
- humans, dry eye syndromes, vitamin d, health surveys, risk factors, cross-sectional studies, sunlight, adult, aged, aged, 80 and over, middle aged, female, male, young adult
7 autores
- Sam Young Yoon🇰🇷Hallym University
- Seok Hyun Bae🇰🇷Hallym University
- Young Joo Shin🇰🇷 · autor de correspondenciaHallym University
- Shin Goo Park🇰🇷Inha University
- Sang-Hee Hwang🇰🇷Keimyung University
- Joon Young Hyon🇰🇷Seoul National University; Seoul National University Bundang Hospital
- Won Ryang Wee🇰🇷Seoul National University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dry eye syndrome (DES) is a common tear film and ocular surface disease that results in discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. Systemic diseases associated with DES include diabetes mellitus, rheumatoid arthritis, depression, anxiety, thyroid disease, allergic diseases, irritable bowel syndrome, chronic pain syndrome, and hyperlipidemia. Interestingly, it has been found that most of these are associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) or inadequate sunlight exposure.
Methods
In this cross-sectional data analysis, noninstitutionalized adults aged ≥19 years (N = 17,542) who participated in Korean National Health and Nutrition Examination Survey 2010-2012 were included. Information regarding duration of sunlight exposure was collected from the survey participants. Serum 25(OH)D and zinc levels were measured. The confounding variables were age, gender, sunlight exposure time, region of residence, obesity, serum 25(OH)D level, diabetes mellitus, rheumatoid arthritis, depression, thyroid disorder, atopic dermatitis, history of ocular surgery, regular exercise, and walking exercise.
Results
Mean serum 25(OH)D levels of subjects with and without DES were 16.90 ± 6.0 and 17.52 ± 6.07 (p<0.001). Inadequate sunlight exposure time (odds ratio [OR], 1.554; 95% confidence interval [CI], 1.307-1.848), urban residence (OR, 1.669; 95% CI, 1.456-1.913), indoor occupation (OR, 1.578; 95% CI, 1.389-1.814), and low serum 25(OH)D level (OR, 1.158; 95% CI, 1.026-1.308) were the risk factors for DES. After adjusting for age, sex, obesity, diabetes mellitus, rheumatoid arthritis, depression, thyroid disorder, atopic dermatitis, history of ocular surgery, regular exercise, and occupation, low serum 25(OH)D level (OR, 1.178; 95% CI, 1.010-1.372) and deficient sunlight exposure time (OR, 1.383; 95% CI, 1.094-1.749) were the risk factors for diagnosed DES.
Conclusion
Low serum 25(OH)D levels and inadequate sunlight exposure are associated with DES in Korean adults. These results suggest that sufficient sunlight exposure or vitamin D supplementation may be useful in DES treatment.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.