Financiado en parte por Novo Nordisk Fonden
Vitamin D 20,000 IU per Week for Five Years Does Not Prevent Progression From Prediabetes to Diabetes
Jorde R, Sollid ST, Svartberg J, Schirmer H, Joakimsen RM, Njølstad I, Fuskevåg OM, Figenschau Y, Hutchinson MY
The Journal of clinical endocrinology and metabolism · 152 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Novo Nordisk Fonden
- Subvenciones
- Novo Nordisk Fonden (NNF12OC1016126)
Según 1 financiador declarado.
Publicación
- Publicado
- 2016-02-01 · J Clin Endocrinol Metab · vol. 101 · número 4 · págs. 1647–1655
- Editorial
- Oxford University Press
- Citado
- 203 citas · más que el 100% de estudios similares · 19.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Diabetes, Cardiovascular Risks, and Lipoproteins · Diabetes Treatment and Management
- Palabras clave
- vitamin D supplementation, prediabetes, type 2 diabetes prevention, vitamin D3, 25-hydroxyvitamin D, insulin resistance, oral glucose tolerance test, serum lipids, blood pressure
- MeSH
- humans, diabetes mellitus, type 2, prediabetic state, insulin resistance, vitamin d deficiency, blood glucose, vitamins, vitamin d, glucose tolerance test, dietary supplements, middle aged, female, male, glycated hemoglobin
9 autores
- Rolf Jorde · autor de correspondencia
- Stina Therese Sollid
- Johan Bernhard Svartberg
- Henrik Schirmer
- Ragnar Martin Joakimsen
- Inger Njølstad🇳🇴UiT The Arctic University of Norway
- Ole‐Martin Fuskevåg🇳🇴University Hospital of North Norway
- Yngve Figenschau🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Moira Y. S. Hutchinson🇳🇴Nordland Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Vitamin D deficiency is associated with insulin resistance and risk of future diabetes.
Objective
The objective of the study was to test whether supplementation with vitamin D to subjects with prediabetes will prevent progression to type 2 diabetes mellitus (T2DM).
Design
This was a randomized controlled trial performed in 2008 through 2015.
Setting
The study was conducted at the clinical research unit at a teaching hospital.
Patients
Five hundred eleven subjects (mean age 62 y, 314 males) with prediabetes diagnosed with an oral glucose tolerance test as part of the Tromsø Study 2007–2008 were included. A total of 256 were randomized to vitamin D and 255 to placebo. Twenty-nine subjects in the vitamin D and 24 in the placebo group withdrew because of adverse events.
Interventions
Interventions included vitamin D (cholecalciferol) 20 000 IU/wk vs placebo for 5 years. Annual oral glucose tolerance tests were performed.
Main outcome measure
Progression to T2DM was the main outcome measure. Secondary outcomes were change in glucose levels, insulin resistance, serum lipids, and blood pressure.
Results
The mean baseline serum 25-hydroxyvitamin D level was 60 nmol/L (24 ng/mL). One hundred three in the vitamin D and 112 in the placebo group developed T2DM (hazard risk 0.90; 95% confidence interval 0.69–1.18, Cox regression, P = .45, intention to treat analysis). No consistent significant effects on the other outcomes were seen. Subgroup analyses in subjects with low baseline 25-hydroxyvitamin D yielded similar results. No serious side effects related to the intervention were recorded.
Conclusions
In subjects without vitamin D deficiency, vitamin D supplementation is unlikely to prevent progression from prediabetes to diabetes. Very large studies with inclusion of vitamin D-deficient subjects will probably be needed to show such a putative effect. This study tested if supplementation with vitamin D to subjects with prediabetes will prevent progression to type 2 diabetes (T2DM).
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