Whey protein, amino acids, and vitamin D supplementation with physical activity increases fat-free mass and strength, functionality, and quality of life and decreases inflammation in sarcopenic elderly
Rondanelli M, Klersy C, Terracol G, Talluri J, Maugeri R, Guido D, Faliva MA, Solerte BS, Fioravanti M, Lukaski H, Perna S
The American journal of clinical nutrition · 294 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Italian Ministry of the University and Research to the University of Pavia Department of Public Health
Según 1 financiador declarado.
Publicación
- Publicado
- 2016-02-11 · Am J Clin Nutr · vol. 103 · número 3 · págs. 830–840
- Editorial
- Elsevier BV
- Citado
- 411 citas · más que el 100% de estudios similares · 27.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 78 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutrition and Health in Aging · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- sarcopenia, whey protein, essential amino acids, leucine, vitamin D supplementation, physical activity, fat-free mass, muscle strength, physical function, quality of life, malnutrition, inflammation, C-reactive protein, insulin-like growth factor I, older adults, body composition
- MeSH
- muscle, skeletal, body fluid compartments, humans, malnutrition, inflammation, vitamin d, amino acids, essential, c-reactive protein, insulin-like growth factor binding protein 1, exercise, activities of daily living, body composition, nutritional status, quality of life, dietary supplements, aged, aged, 80 and over, female, male, muscle strength, sarcopenia, whey proteins
11 autores
- Mariangela Rondanelli🇮🇹 · autor de correspondenciaUniversity of Pavia; Azienda di Servizi alla Persona di Pavia (Italy)
- Catherine Klersy🇮🇹Policlinico San Matteo Fondazione
- Gilles Terracol
- Jacopo Talluri
- Roberto Maugeri
- Davide Guido
- Milena Anna Faliva
- Bruno Solerte🇮🇹University of Pavia
- Marisa Fioravanti🇮🇹University of Pavia
- Henry C. Lukaski🇺🇸University of North Dakota
- Simone Perna
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Interventions to attenuate the adverse effects of age-related loss of skeletal muscle and function include increased physical activity and nutritional supplementation.
Objective
This study tested the hypothesis that nutritional supplementation with whey protein (22 g), essential amino acids (10.9 g, including 4 g leucine), and vitamin D [2.5 μg (100 IU)] concurrent with regular, controlled physical activity would increase fat-free mass, strength, physical function, and quality of life, and reduce the risk of malnutrition in sarcopenic elderly persons.
Design
A total of 130 sarcopenic elderly people (53 men and 77 women; mean age: 80.3 y) participated in a 12-wk randomized, double-blind, placebo-controlled supplementation trial. All participants concurrently took part in a controlled physical activity program. We examined body composition with dual-energy X-ray absorptiometry, muscle strength with a handgrip dynamometer, and blood biochemical indexes of nutritional and health status, and evaluated global nutritional status, physical function, and quality of life before and after the 12 wk of intervention.
Results
Compared with physical activity and placebo, supplementation plus physical activity increased fat-free mass (1.7-kg gain, P < 0.001), relative skeletal muscle mass (P = 0.009), android distribution of fat (P = 0.021), handgrip strength (P = 0.001), standardized summary scores for physical components (P = 0.030), activities of daily living (P = 0.001), mini nutritional assessment (P = 0.003), and insulin-like growth factor I (P = 0.002), and lowered C-reactive protein (P = 0.038).
Conclusion
Supplementation with whey protein, essential amino acids, and vitamin D, in conjunction with age-appropriate exercise, not only boosts fat-free mass and strength but also enhances other aspects that contribute to well-being in sarcopenic elderly. This trial was registered at clinicaltrials.gov as NCT02402608.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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