The Circulating Concentration and 24-h Urine Excretion of Magnesium Dose- and Time-Dependently Respond to Oral Magnesium Supplementation in a Meta-Analysis of Randomized Controlled Trials
Zhang X, Del Gobbo LC, Hruby A, Rosanoff A, He K, Dai Q, Costello RB, Zhang W, Song Y
The Journal of nutrition · 49 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Indiana University Health-Indiana University School of Medicine Strategic Research Initiative
Según 1 financiador declarado.
Publicación
- Publicado
- 2016-02-11 · J Nutr · vol. 146 · número 3 · págs. 595–602
- Editorial
- Elsevier BV
- Citado
- 64 citas · más que el 83% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Magnesium Alloys: Properties and Applications · Magnesium Oxide Properties and Applications
- Palabras clave
- magnesium supplementation, oral magnesium, serum magnesium, plasma magnesium, dose-response relationship, time response, steady state, red blood cell magnesium, urinary calcium, magnesium status assessment
- MeSH
- humans, magnesium, administration, oral, nutrition assessment, dose-response relationship, drug, time factors, dietary supplements, randomized controlled trials as topic, biomarkers
9 autores
- Xi Zhang🇺🇸Indiana University Indianapolis
- Liana C. Del Gobbo🇺🇸Stanford Medicine; Stanford University
- Adela Hruby🇺🇸Harvard University
- Andrea Rosanoff
- Ka He🇺🇸Indiana University Bloomington; Indiana University
- Qi Dai🇺🇸Vanderbilt University; VA Tennessee Valley Healthcare System; Vanderbilt-Ingram Cancer Center
- Rebecca B. Costello
- Wen Zhang🇯🇵Fukushima Medical University
- Yiqing Song🇺🇸 · autor de correspondenciaIndiana University Indianapolis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Accurate determination of Mg status is important for improving nutritional assessment and clinical risk stratification.
Objective
We aimed to quantify the overall responsiveness of Mg biomarkers to oral Mg supplementation among adults without severe diseases and their dose- and time responses using available data from randomized controlled trials (RCTs).
Methods
We identified 48 Mg supplementation trials (n = 2131) through searches of MEDLINE and the Cochrane Library up to November 2014. Random-effects meta-analysis was used to estimate weighted mean differences of biomarker concentrations between intervention and placebo groups. Restricted cubic splines were used to determine the dose- and time responses of Mg biomarkers to supplementation.
Results
Among the 35 biomarkers assessed, serum, plasma, and urine Mg were most commonly measured. Elemental Mg supplementation doses ranged from 197 to 994 mg/d. Trials ranged from 3 wk to 5 y (median: 12 wk). Mg supplementation significantly elevated circulating Mg by 0.04 mmol/L (95% CI: 0.02, 0.06) and 24-h urine Mg excretion by 1.52 mmol/24 h (95% CI: 1.20, 1.83) as compared to placebo. Circulating Mg concentrations and 24-h urine Mg excretion responded to Mg supplementation in a dose- and time-dependent manner, gradually reaching a steady state at doses of 300 mg/d and 400 mg/d, or after ~20 wk and 40 wk, respectively (all P-nonlinearity ≤ 0.001). The higher the circulating Mg concentration at baseline, the lower the responsiveness of circulating Mg to supplementation, and the higher the urinary excretion (all P-linearity < 0.05). In addition, RBC Mg, fecal Mg, and urine calcium were significantly more elevated by Mg supplementation than by placebo (all P-values < 0.05), but there is insufficient evidence to determine their responses to increasing Mg doses.
Conclusions
This meta-analysis of RCTs demonstrated significant dose- and time responses of circulating Mg concentration and 24-h urine Mg excretion to oral Mg supplementation.
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