Acute effects of theanine, caffeine and theanine-caffeine combination on attention
Kahathuduwa CN, Dassanayake TL, Amarakoon AMT, Weerasinghe VS
Nutritional neuroscience · 41 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Council Grant, Sri Lanka
Según 1 financiador declarado.
Publicación
- Publicado
- 2016-02-12 · Nutr Neurosci · vol. 20 · número 6 · págs. 369–377
- Editorial
- Taylor & Francis
- Citado
- 71 citas · más que el 92% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Tea Polyphenols and Effects · Coffee research and impacts · Sirtuins and Resveratrol in Medicine
- Palabras clave
- Caffeine, Theanine, Placebo, Crossover study, Neurophysiology, Evoked potential, Cognition, Anesthesia, Pharmacology, Psychology, Audiology, Medicine, Internal medicine, Chemistry, Neuroscience, Food science, Green tea
- MeSH
- humans, caffeine, glutamates, nootropic agents, cross-over studies, motor activity, cognition, pattern recognition, visual, attention, reaction time, evoked potentials, motor, evoked potentials, visual, students, universities, coffee, tea, dietary supplements, adult, sri lanka, male, young adult, performance-enhancing substances
4 autores
- Chanaka Nadeeshan Kahathuduwa🇱🇰🇺🇸University of Peradeniya; Texas Tech University
- Tharaka L. Dassanayake🇱🇰 · autor de correspondenciaUniversity of Peradeniya
- A. M. T. Amarakoon🇱🇰University of Kelaniya
- Vajira Senaka Weerasinghe🇱🇰University of Peradeniya
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
l-theanine is a constituent of tea which is claimed to enhance cognitive functions. We aimed to determine whether theanine and theanine-caffeine combination have acute positive effects on cognitive and neurophysiological measures of attention, compared to caffeine (a positive control) and a placebo in healthy individuals.
Design
In a placebo-controlled, five-way crossover trial in 20 healthy male volunteers, we compared the effects of l-theanine (200 mg), caffeine (160 mg), their combination, black tea (one cup) and a placebo (distilled water) on cognitive (simple [SVRT] and recognition visual reaction time [RVRT]) and neurophysiological (event-related potentials [ERPs]) measures of attention. We also recorded visual (VEPs) and motor evoked potentials (MEPs) to examine any effects of treatments on peripheral visual and motor conduction, respectively.
Results
Mean RVRT was significantly improved by theanine (P = 0.019), caffeine (P = 0.043), and theanine-caffeine combination (P = 0.001), but not by tea (P = 0.429) or placebo (P = 0.822). VEP or MEP latencies or SVRT did not show significant inter-treatment differences. Theanine (P = 0.001) and caffeine (P = 0.001) elicited significantly larger mean peak-to-peak N2-P300 ERP amplitudes than the placebo, whereas theanine-caffeine combination elicited a significantly larger mean N2-P300 amplitude than placebo (P < 0.001), theanine (P = 0.029) or caffeine (P = 0.005). No significant theanine × caffeine interaction was observed for RVRT or N2-P300 amplitude.
Discussion
A dose of theanine equivalent of eight cups of back tea improves cognitive and neurophysiological measures of selective attention, to a degree that is comparable with that of caffeine. Theanine and caffeine seem to have additive effects on attention in high doses.
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