Impact of Omega-3 Fatty Acid Supplementation on Memory Functions in Healthy Older Adults
Külzow N, Witte AV, Kerti L, Grittner U, Schuchardt JP, Hahn A, Flöel A
Journal of Alzheimer's disease : JAD · 104 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-03-30 · J Alzheimers Dis · vol. 51 · número 3 · págs. 713–725
- Editorial
- IOS Press
- Citado
- 141 citas · más que el 99% de estudios similares · 10.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Biochemical effects in animals · Diet and metabolism studies
- Palabras clave
- Omega, Omega 3 fatty acid, Gerontology, Fatty acid, Medicine, Internal medicine, Psychology, Physiology, Docosahexaenoic acid, Chemistry, Biochemistry, Polyunsaturated fatty acid, Philosophy
- MeSH
- humans, fatty acids, omega-3, apolipoproteins e, nootropic agents, blood chemical analysis, treatment outcome, double-blind method, feeding behavior, learning, memory, auditory perception, neuropsychological tests, dietary supplements, aged, middle aged, female, male, cognitive aging
7 autores
- Nadine Külzow🇩🇪 · autor de correspondenciaNeuroCure Cluster of Excellence; Charité - Universitätsmedizin Berlin
- A. Veronica Witte🇩🇪Max Planck Institute for Human Cognitive and Brain Sciences
- Lucia Kerti🇩🇪Center for Stroke Research Berlin; Charité - Universitätsmedizin Berlin
- Ulrike Grittner🇩🇪Charité - Universitätsmedizin Berlin
- Jan Philipp Schuchardt🇩🇪Leibniz University Hannover
- Andreas Hahn🇩🇪Leibniz University Hannover
- Agnes Flöel🇩🇪 · autor de correspondenciaNeuroCure Cluster of Excellence; Center for Stroke Research Berlin; Charité - Universitätsmedizin Berlin
Resumen
El texto original del estudio, en el idioma en que se publicó.
As the process of Alzheimer's disease (AD) begins years before disease onset, searching for prevention strategies is of major medical and economic importance. Nutritional supplementation with long-chain polyunsaturated omega-3 fatty acids (LC-n3-FA) may exert beneficial effects on brain structure and function. However, experimental evidence in older adults without clinical dementia is inconsistent, possibly due to low sensitivity of previously employed test batteries for detecting subtle improvements in cognition in healthy individuals. Here we used LOCATO, recently described as a robust and sensitive tool for assessing object-location memory (OLM) in older adults, to evaluate the impact of LC-n3-FA supplementation on learning and memory formation. In a double-blind placebo-controlled proof-of-concept study, 44 (20 female) cognitively healthy individuals aged 50-75 years received either LC-n3-FA (2,200 mg/day, n = 22) or placebo (n = 22) for 26 weeks. Before and after intervention, memory performance in the OLM-task (primary) was tested. As secondary outcome parameters, performance in Rey Auditory Verbal Learning Test (AVLT), dietary habits, omega-3-index, and other blood-derived parameters were assessed. Omega-3 index increased significantly in the LC-n3-FA group compared with the placebo group. Moreover, recall of object locations was significantly better after LC-n3-FA supplementation compared with placebo. Performance in the AVLT was not significantly affected by LC-n3-FA. This double-blind placebo-controlled proof-of-concept study provides further experimental evidence that LC-n3-FA exert positive effects on memory functions in healthy older adults. Our findings suggest novel strategies to maintain cognitive functions into old age.
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