Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women
Belury MA, Cole RM, Bailey BE, Ke JY, Andridge RR, Kiecolt-Glaser JK
Molecular nutrition & food research · 52 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NIH-NCI
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R01 CA186720); National Cancer Institute (R01 CA186251); National Cancer Institute (R21 CA158868); National Cancer Institute (R21 CA154054); National Cancer Institute (K05 CA172296)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2016-02-29 · Mol Nutr Food Res · vol. 60 · número 5 · págs. 1206–1212
- Editorial
- Wiley
- Citado
- 59 citas · más que el 92% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- Insulin resistance, Linoleic acid, Adipose tissue, Oleic acid, Internal medicine, Endocrinology, Composition (language), Lean body mass, Obesity, Fatty acid, Chemistry, Biology, Biochemistry, Medicine, Body weight
- MeSH
- erythrocytes, humans, insulin resistance, fatty acids, omega-3, linoleic acid, oleic acid, c-reactive protein, interleukin-6, body mass index, cohort studies, cross-sectional studies, body composition, dietary supplements, adult, middle aged, female, male
6 autores
- Martha Ann Belury🇺🇸 · autor de correspondenciaNew York State University College of Human Ecology; The Ohio State University
- Rachel M. Cole🇺🇸New York State University College of Human Ecology; The Ohio State University
- Brittney E. Bailey🇺🇸Ohio Department of Health; Institute for Behavioral Medicine
- Jia‐Yu Ke🇺🇸New York State University College of Human Ecology; The Ohio State University
- Rebecca Andridge🇺🇸Ohio Department of Health
- Janice K. Kiecolt‐Glaser🇺🇸Institute for Behavioral Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
Supplementation with linoleic acid (LA; 18:2Ω6)-rich oils increases lean mass and decreases trunk adipose mass in people. Erythrocyte fatty acids reflect the dietary pattern of fatty acid intake and endogenous metabolism of fatty acids. The aim of this study is to determine the relationship of erythrocyte LA, with aspects of body composition, insulin resistance, and inflammation. Additionally, we tested for relationships of oleic acid (OA) and the sum of long chain omega-three fatty acids (LC-Ω3-SUM), on the same outcomes.
Methods and results
Men and women (N = 139) were evaluated for body composition, insulin resistance, and serum inflammatory markers, IL-6, and c-reactive protein (CRP) and erythrocyte fatty acid composition after an overnight fast. LA was positively related to appendicular lean mass/body mass index and inversely related to trunk adipose mass. Additionally, LA was inversely related to insulin resistance and IL-6. While there was an inverse relationship between OA or LC-Ω3-SUM with markers of inflammation, there were no relationships between OA or LC-Ω3-SUM with body composition or HOMA-IR.
Conclusion
Higher erythrocyte LA was associated with improved body composition, insulin resistance, and inflammation. Erythrocyte OA or LC-Ω3-SUM was unrelated to body composition and insulin resistance. There is much controversy about whether all unsaturated fats have the same benefits for metabolic syndrome and weight gain. We sought to test the strength of the relationships between three unsaturated fatty acid in erythrocytes with measurements of body composition, metabolism, and inflammation in healthy adults. Linoleic acid, but not oleic acid or the sum of long-chain omega 3 fatty acids (w3), was associated with increased appendicular lean mass and decreased trunk adipose mass and insulin resistance.
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