Whole Grain Intake Reduces Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies
Lei Q, Zheng H, Bi J, Wang X, Jiang T, Gao X, Tian F, Xu M, Wu C, Zhang L, Li N, Li J
Medicine · 37 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-03-01 · Medicine (Baltimore) · vol. 95 · número 9 · pág. e2747
- Editorial
- Wolters Kluwer
- Citado
- 49 citas · más que el 93% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-ND
- Áreas de investigación
- Pancreatic and Hepatic Oncology Research · Pancreatitis Pathology and Treatment · Esophageal and GI Pathology
- Palabras clave
- Medicine, Pancreatic cancer, Odds ratio, Subgroup analysis, Confidence interval, Internal medicine, Meta-analysis, Epidemiology, Gastroenterology, Cochrane Library, Cancer
- MeSH
- humans, pancreatic neoplasms, dietary fiber, protective factors, observational studies as topic, whole grains
12 autores
- Qiucheng Lei🇨🇳Nanjing Medical University
- Huazhen Zheng🇨🇳Guangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Jingcheng Bi🇨🇳Guangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Xinying Wang🇨🇳 · autor de correspondenciaGuangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Tingting Jiang🇨🇳 · autor de correspondenciaGuangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Xuejin Gao🇨🇳Guangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Feng Tian🇨🇳Guangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Min Xu🇨🇳 · autor de correspondenciaGuangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Chao Wu🇨🇳Guangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Li Zhang🇨🇳Guangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Ning Li🇨🇳Guangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
- Jieshou Li🇨🇳Guangdong Medical College; Nanjing General Hospital of Nanjing Military Command; Key Laboratory of Guangdong Province; Second Affiliated Hospital of Nanjing Medical University; Jinling Institute of Technology; Southern Medical University; Nanjing Medical University; Nanjing University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Mounting evidence from epidemiology studies suggests that whole grain intake may reduce pancreatic cancer risk, but convincing evidence is scarce. We conducted a meta-analysis to assess the association between whole grain intake and pancreatic cancer risk. Relevant observational studies were identified by searching PubMed, Embase, Scopus, and Cochrane library databases for the period from January 1980 to July 2015, with no restrictions. We calculated the summary odds ratios (ORs) for pancreatic cancer using random-effects model meta-analysis. Between-study heterogeneity was analyzed using the I statistic. A total of 8 studies regarding whole grain intake were included in the meta-analysis. The pooled OR of pancreatic cancer for those with high versus low whole grain intake was 0.76 (95% confidence interval [CI], 0.64-0.91; P = 0.002). There was no significant heterogeneity across these studies (I² = 11.7%; Pheterogeneity = 0.339). In the subgroup analysis by geographic area, the summary ORs of developing pancreatic cancer were 0.64 (95% CI, 0.53-0.79; P < 0.001; I ²= 0%; Pheterogeneity = 0.482) in the United States (n = 4) and 0.95 (95% CI, 0.63-1.43; P = 0.803; I ²= 45.6%; Pheterogeneity = 0.175) in Europe (n = 2). In the subgroup analysis by type of whole grain, the summary ORs were 0.72 (95% CI, 0.60-0.87; P = .001; I² = 0; Pheterogeneity = 0.876) for grains (n = 4) and 0.74 (95% CI, 0.27-2.02; P = 0.554; I² = 86.3%; Pheterogeneity = 0.007) for wheat (n = 2). A high intake of whole grains was associated with a reduced risk of pancreatic cancer. Because of the absent of more cohort studies, further prospective studies need to be conducted to ensure conclusions that are more robust.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-ND).
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