Long-Term Fish Oil Lipid Emulsion Use in Children With Intestinal Failure-Associated Liver Disease [Formula: see text]
Nandivada P, Fell GL, Mitchell PD, Potemkin AK, O'Loughlin AA, Gura KM, Puder M
JPEN. Journal of parenteral and enteral nutrition · 39 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Boston Children's Hospital
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Child Health and Human Development
- Universidad u hospital
- Boston Children's Hospital
- Subvenciones
- National Institute of Child Health and Human Development (1F32DK104525‐01); National Institutes of Health (1f32dk104525-01)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2016-03-09 · JPEN J Parenter Enteral Nutr · vol. 41 · número 6 · págs. 930–937
- Editorial
- Wiley
- Citado
- 51 citas · más que el 97% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Liver Disease and Transplantation · Infant Nutrition and Health
- Palabras clave
- Medicine, Transplantation, Parenteral nutrition, Intestinal failure, Liver disease, Liver transplantation, Fish oil, Internal medicine, Gastroenterology, Short bowel syndrome, Surgery, Fish <Actinopterygii>, Biology
- MeSH
- humans, intestinal diseases, liver failure, chronic disease, soybean oil, fat emulsions, intravenous, fatty acids, essential, fish oils, parenteral nutrition, endpoint determination, retrospective studies, child development, infant, infant, newborn, female, male, biomarkers
7 autores
- Prathima Nandivada🇺🇸Boston Children's Hospital; Harvard University
- Gillian L. Fell🇺🇸Boston Children's Hospital; Harvard University
- Paul D. Mitchell🇺🇸Boston Children's Hospital; Boston Children's Museum
- Alexis K. Potemkin🇺🇸Boston Children's Hospital; Harvard University
- Alison A. O’Loughlin🇺🇸Boston Children's Hospital; Harvard University
- Kathleen M. Gura🇺🇸Boston Children's Hospital; Boston Children's Museum
- Mark Puder🇺🇸 · autor de correspondenciaBoston Children's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Fish oil lipid emulsion (FOLE) and multidisciplinary care for infants with intestinal failure (IF) have been associated with reduced morbidity and mortality due to IF-associated liver disease (IFALD). With increased survival, a greater proportion of infants with IF are now able to remain on parenteral nutrition (PN) in the long term. The purpose of this study was to examine outcomes in children with IFALD who have required long-term PN and FOLE therapy due to chronic IF.
Materials and methods
A review of prospectively collected data was performed for children with IFALD who required at least 3 years of PN and FOLE therapy due to chronic IF. Outcomes examined include the incidence of death, transplantation, and essential fatty acid deficiency (EFAD), as well as growth parameters and the biochemical markers of liver disease.
Results
Of 215 patients with IFALD treated from 2004-2015, 30 required PN and FOLE therapy for at least 3 years (median, 4.6 years). To date, no patients have died, required transplantation, or developed EFAD. Biochemical markers of liver disease normalized within the first year of therapy with no recurrent elevations in the long term. Weight-for age and length-for-age z scores improved and PN dependence decreased in the first year of therapy, with a stable rate of growth in the long term.
Conclusions
Children with IFALD who required long-term PN and FOLE for chronic IF had no mortality, need for transplantation, EFAD, or recurrence of liver disease in the long term, allowing for continued intestinal rehabilitation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.