Association between serum 25-hydroxyvitamin D and serum sex steroid hormones among men in NHANES
Anic GM, Albanes D, Rohrmann S, Kanarek N, Nelson WG, Bradwin G, Rifai N, McGlynn KA, Platz EA, Mondul AM
Clinical endocrinology · 37 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- New York City Department of Health and Mental Hygiene
- Gobierno
- Maryland Department of Health and Mental Hygiene
- Universidad u hospital
- Johns Hopkins University
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- Intramural NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (P30CA 006973); National Cancer Institute (CA006973); Johns Hopkins University (P30CA006973); National Institutes of Health (Z99 CA999999); National Institutes of Health (P30-CA006973); National Institutes of Health (CA006973)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2016-03-19 · Clin Endocrinol (Oxf) · vol. 85 · número 2 · págs. 258–266
- Editorial
- Wiley
- Citado
- 47 citas · más que el 93% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Hormonal and reproductive studies · Estrogen and related hormone effects
- Palabras clave
- National Health and Nutrition Examination Survey, Internal medicine, Sex hormone-binding globulin, Endocrinology, Vitamin D and neurology, Medicine, Testosterone (patch), Hormone, Prostate cancer, Body mass index, Confidence interval, Androgen, Population, Cancer
- MeSH
- adipose tissue, humans, prostatic neoplasms, gonadal steroid hormones, prostate-specific antigen, vitamin d, sex hormone-binding globulin, body mass index, cross-sectional studies, adult, male, waist circumference, ethnicity, racial groups
10 autores
- Gabriella M. Anic🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Demetrius Albanes🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Sabine Rohrmann🇨🇭🇺🇸University of Zurich; Prevention Institute
- Norma Kanarek🇺🇸Johns Hopkins University; Sidney Kimmel Comprehensive Cancer Center
- William G. Nelson🇺🇸Johns Hopkins University; Johns Hopkins Medicine; Sidney Kimmel Comprehensive Cancer Center
- Gary Bradwin🇺🇸Boston Children's Hospital; Harvard University
- Nader Rifai🇺🇸Boston Children's Hospital; Harvard University
- Katherine A. McGlynn🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Elizabeth A. Platz🇺🇸Johns Hopkins University; Johns Hopkins Medicine; Sidney Kimmel Comprehensive Cancer Center
- Alison M. Mondul🇺🇸 · autor de correspondenciaUniversity of Michigan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Recent literature suggests that high circulating vitamin D may increase prostate cancer risk. Although the mechanism through which vitamin D may increase risk is unknown, vitamin D concentration could influence circulating sex steroid hormones that may be associated with prostate cancer; an alternate explanation is that it could be associated with prostate-specific antigen (PSA) concentration causing detection bias.
Objective
We examined whether serum vitamin D concentration was associated with sex steroid hormone and PSA concentrations in a cross-sectional analysis of men in the National Health and Nutrition Examination Surveys (NHANES).
Design
Testosterone, oestradiol, sex hormone-binding globulin (SHBG), androstanediol glucuronide, and 25-hydroxyvitamin D (25(OH)D) were measured in serum from men aged 20 and older participating in NHANES III (n = 1315) and NHANES 2001-2004 (n = 318). Hormone concentrations were compared across 25(OH)D quintiles, adjusting for age, race/ethnicity, body fat percentage, and smoking. PSA concentration was estimated by 25(OH)D quintile in 4013 men from NHANES 2001-2006.
Results
In NHANES III, higher testosterone (quintile (Q) 1 = 17·2, 95% confidence interval (CI) = 16·1-18·6; Q5 = 19·6, 95% CI = 18·7-20·6 nmol/l, P-trend = 0·0002) and SHBG (Q1 = 33·8, 95% CI = 30·8-37·0; Q5 = 38·4, 95% CI = 35·8-41·2 nmol/l, P-trend = 0·0005) were observed with increasing 25(OH)D. Similar results were observed in NHANES 2001-2004. PSA concentration was not associated with serum 25(OH)D (P-trend = 0·34).
Conclusion
Results from these nationally representative studies support a positive association between serum 25(OH)D and testosterone and SHBG. The findings support an indirect mechanism through which vitamin D may increase prostate cancer risk, and suggest the link to prostate cancer is not due to PSA-detection bias.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.