Egg consumption and risk of type 2 diabetes: a prospective study and dose-response meta-analysis
Wallin A, Forouhi NG, Wolk A, Larsson SC
Diabetologia · 33 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Karolinska Institutet
- Gobierno
- Vetenskapsrådet
- Gobierno
- Medical Research Council
- Gobierno
- Swedish Research Council/Committee for Research Infrastructure
- Gobierno
- MRC support
- Universidad u hospital
- Karolinska Institutet’s Strategic Program in Epidemiology
- Subvenciones
- Medical Research Council (MC_UU_12015/5); Medical Research Council (MC_UU_12015/5); Medical Research Council (MC_UU_12015)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-03-18 · Diabetologia · vol. 59 · número 6 · págs. 1204–1213
- Editorial
- Springer Science+Business Media
- Citado
- 46 citas · más que el 97% de estudios similares · 7.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Obesity, Physical Activity, Diet · Phytoestrogen effects and research
- Palabras clave
- Medicine, Meta-analysis, Type 2 diabetes, Prospective cohort study, Diabetes mellitus, Proportional hazards model, Internal medicine, Cohort study, Hazard ratio, Confidence interval, Lower risk, Demography, Endocrinology
- MeSH
- humans, diabetes mellitus, type 2, diet surveys, proportional hazards models, risk factors, prospective studies, eggs, aged, middle aged, sweden, female, male, surveys and questionnaires
4 autores
- Alice Wallin🇸🇪 · autor de correspondenciaKarolinska Institutet
- Nita G. Forouhi🇬🇧University of Cambridge; MRC Epidemiology Unit; Medical Research Council
- Alicja Wolk🇸🇪Karolinska Institutet
- Susanna C. Larsson🇸🇪Karolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims/hypothesis
In this study, we aimed to investigate the association between egg consumption and type 2 diabetes risk in the Cohort of Swedish Men and to conduct a meta-analysis to summarise available prospective evidence on this association.
Methods
We followed 39,610 men (aged 45-79 years) from 1998 up to 2012 for incident type 2 diabetes. Egg consumption was assessed at baseline using a food frequency questionnaire. HRs (95% CIs) were estimated using Cox proportional hazards regression models. We searched PubMed (up to 14 December 2015) and reference lists of retrieved articles to identify eligible studies for meta-analysis.
Results
During the 15 years of follow up, 4,173 men were diagnosed with type 2 diabetes. Compared with men who consumed eggs <1 time/week, the multivariable-adjusted HRs were 0.98 (95% CI 0.92, 1.05), 1.11 (95% CI 0.99, 1.24) and 1.11 (95% CI 0.95, 1.29) for egg consumption 1-2, 3-4 and ≥5 times/week, respectively (p trend = 0.06). In a random-effects dose-response meta-analysis, heterogeneity in the overall estimate was partly explained by differences across regions. The overall HRs for type 2 diabetes for each 3 times/week increment in consumption were 1.18 (95% CI 1.13, 1.24) in five US studies (I (2) = 0%) and 0.97 (95% CI 0.90, 1.05) in seven non-US studies.
Conclusions/interpretation
Our findings in Swedish men do not support an association between egg consumption and risk of type 2 diabetes. In a meta-analysis, frequent egg consumption was associated with a higher risk of type 2 diabetes in US studies only. Egg consumption habits and associated overall dietary patterns may differ between populations and could potentially explain the discrepancies between reported results. Given the inconsistent results, this relationship warrants further study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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