Financiado en parte por Gatorade Sports Science Institute
Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men
McGlory C, Wardle SL, Macnaughton LS, Witard OC, Scott F, Dick J, Bell JG, Phillips SM, Galloway SD, Hamilton DL, Tipton KD
Physiological reports · 74 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Gatorade Sports Science Institute
- Sin clasificar
- Sporting Chance Initiative
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-03-01 · Physiol Rep · vol. 4 · número 6 · pág. e12715
- Editorial
- Wiley
- Citado
- 105 citas · más que el 97% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Cardiovascular and exercise physiology
- Palabras clave
- Anabolism, Ingestion, Endocrinology, Internal medicine, Medicine, Fish oil, Skeletal muscle, Biology, Fish <Actinopterygii>
- MeSH
- myofibrils, muscle, skeletal, humans, ribosomal protein s6 kinases, 70-kda, phospholipids, fish oils, muscle proteins, dietary proteins, anabolic agents, biopsy, treatment outcome, signal transduction, protein biosynthesis, phosphorylation, time factors, dietary supplements, scotland, male, proto-oncogene proteins c-akt, resistance training, amp-activated protein kinases, young adult
11 autores
- Chris McGlory🇬🇧🇨🇦 · autor de correspondenciaUniversity of Stirling; McMaster University
- Sophie Louise Wardle🇬🇧University of Stirling
- Lindsay S. Macnaughton🇬🇧University of Stirling
- Oliver C. Witard🇬🇧University of Stirling
- Fraser Scott🇬🇧University of Stirling
- James Dick🇬🇧University of Stirling
- John Gordon Bell🇬🇧University of Stirling
- Stuart M. Phillips🇨🇦McMaster University
- Stuart D. R. Galloway🇬🇧University of Stirling
- David Lee Hamilton🇬🇧University of Stirling
- Kevin D. Tipton🇬🇧University of Stirling
Resumen
El texto original del estudio, en el idioma en que se publicó.
Fish oil (FO) supplementation potentiates muscle protein synthesis (MPS) in response to a hyperaminoacidemic-hyperinsulinemic infusion. Whether FO supplementation potentiates MPS in response to protein ingestion or when protein ingestion is combined with resistance exercise (RE) remains unknown. In a randomized, parallel group design, 20 healthy males were randomized to receive 5 g/day of either FO or coconut oil control (CO) for 8 weeks. After supplementation, participants performed a bout of unilateral RE followed by ingestion of 30 g of whey protein. Skeletal muscle biopsies were obtained before and after supplementation for assessment of muscle lipid composition and relevant protein kinase activities. Infusion of L-[ring-(13)C6] phenylalanine was used to measure basal myofibrillar MP Sat rest (REST), in a nonexercised leg following protein ingestion (FED) and following RE and protein ingestion (FEDEX).MPS was significantly elevated above REST during FEDEX in both the FO and CO groups, but there was no effect of supplementation. There was a significant increase in MPS in both groups above REST during FED but no effect of supplementation. Supplementation significantly decreased pan PKB activity at RESTin the FO group but not the CO group. There was a significant increase from REST at post-RE for PKB and AMPKα2 activity in the CO group but not in the FO group. In FEDEX, there was a significant increase in p70S6K1 activity from REST at 3 h in the CO group only. These data highlight that 8 weeks of FO supplementation alters kinase signaling activity in response to RE plus protein ingestion without influencing MPS.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.