Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man
Petrović J, Stanić D, Dmitrašinović G, Plećaš-Solarović B, Ignjatović S, Batinić B, Popović D, Pešić V
Oxidative medicine and cellular longevity · 27 citas
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- Ensayo clínico controlado (indexado por PubMed)
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Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Subvenciones
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (175036)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-01-01 · Oxid Med Cell Longev · vol. 2016 · número 1 · pág. 2019643
- Editorial
- Hindawi Publishing Corporation
- Citado
- 44 citas · más que el 98% de estudios similares · 9.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Childhood Cancer Survivors' Quality of Life · Effects of Radiation Exposure · Therapeutic Uses of Natural Elements
- Palabras clave
- Athletes, Lymphocyte, Peripheral blood, Peripheral blood lymphocyte, Oxidative phosphorylation, Oxidative damage, Immunology, Peripheral, Medicine, Physiology, DNA damage, Oxidative stress, DNA, Endocrinology, Biology, Internal medicine, Physical therapy, Genetics, Biochemistry
- MeSH
- lymphocytes, humans, dna damage, hydrogen peroxide, magnesium, oxidative stress, football, dietary supplements, adult, male, young adult, athletes, sedentary behavior
8 autores
- Jelena Petrović🇷🇸University of Belgrade
- Dušanka Stanić🇷🇸University of Belgrade
- Gordana Dmitrašinović🇷🇸University of Belgrade
- Bosiljka Plećaš‐Solarović🇷🇸University of Belgrade
- Svetlana Ignjatović🇷🇸University of Belgrade
- Bojan Batinić🇷🇸University of Belgrade
- Dejana Popović🇷🇸University of Belgrade
- Vesna Pešić🇷🇸 · autor de correspondenciaUniversity of Belgrade
Resumen
El texto original del estudio, en el idioma en que se publicó.
Sedentary lifestyle is highly associated with increased risk of cardiovascular disease, obesity, and type 2 diabetes. It is known that regular physical activity has positive effects on health; however several studies have shown that acute and strenuous exercise can induce oxidative stress and lead to DNA damage. As magnesium is essential in maintaining DNA integrity, the aim of this study was to determine whether four-week-long magnesium supplementation in students with sedentary lifestyle and rugby players could prevent or diminish impairment of DNA. By using the comet assay, our study demonstrated that the number of peripheral blood lymphocytes (PBL) with basal endogenous DNA damage is significantly higher in rugby players compared to students with sedentary lifestyle. On the other hand, magnesium supplementation significantly decreased the number of cells with high DNA damage, in the presence of exogenous H2O2, in PBL from both students and rugby players, and markedly reduced the number of cells with medium DNA damage in rugby players compared to corresponding control nonsupplemented group. Accordingly, the results of our study suggest that four-week-long magnesium supplementation has marked effects in protecting the DNA from oxidative damage in both rugby players and in young men with sedentary lifestyle. Clinical trial is registered at ANZCTR Trial Id: ACTRN12615001237572.
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