Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis
Lee YH, Bae SC
Clinical and experimental rheumatology · 91 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-01-27 · Clin Exp Rheumatol · vol. 34 · número 5 · págs. 827–833
- Editorial
- National Institutes of Health
- Citado
- 144 citas · más que el 99% de estudios similares · 12.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Rheumatoid Arthritis Research and Therapies · Systemic Lupus Erythematosus Research
- Palabras clave
- rheumatoid arthritis, vitamin D, 25-hydroxyvitamin D, vitamin D deficiency, disease activity, DAS28, serum vitamin D levels
- MeSH
- humans, arthritis, rheumatoid, vitamin d deficiency, disease susceptibility, vitamin d, severity of illness index, prevalence, odds ratio, risk factors, case-control studies, adult, aged, middle aged, biomarkers
2 autores
- Young Ho Lee🇰🇷Korea University; Korea University Medical Center
- Sang‐Cheol Bae🇰🇷Hanyang University Seoul Hospital; Hanyang University Hospital for Rheumatic Disease
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
This study aimed to evaluate the relationship between the 25-hydroxyvitamin D [25(OH)D] level and rheumatoid arthritis (RA) and the correlation between serum vitamin D level and RA activity.
Methods
We searched the PUBMED, EMBASE, and Cochrane databases and performed a meta-analysis examining the vitamin D level and prevalence of vitamin D deficiency in patients with RA compared to healthy controls and the correlation coefficients between the vitamin D level and disease activity score 28 (DAS28) in RA patients.
Results
Fifteen studies that included a total of 1,143 RA patients and 963 controls were available for this meta-analysis. The meta-analysis showed that the serum vitamin D level in the RA group was significantly lower than that in the control group (SMD=-0.608, 95% CI=-1.105-[-0.017], p=0.017). In addition, the prevalence of vitamin D deficiency was significantly higher in the RA group than in the control group (55.2% vs. 33.2%; OR = 2.460, 95% CI = 1.135-5.332, p=0.023). Thirteen studies evaluated the correlation between the vitamin D level and its activity in 924 RA patients. Meta-analysis showed a significant inverse correlation between the vitamin D level and DAS28 (Correlation coefficient =-0.278, 95% CI =-0.393-[-0.153], p=1.8 x 10-5).
Conclusions
Our meta-analysis demonstrates that serum vitamin D level is significantly low in patients with RA, vitamin D deficiency is prevalent in RA patients compared to controls, and the vitamin D level correlates inversely with RA activity. Our meta-analysis suggests that the vitamin D level is associated with susceptibility to RA and RA activity.
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