Financiado en parte por Bio-Tech Pharmacal
Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study
McDonnell SL, Baggerly C, French CB, Baggerly LL, Garland CF, Gorham ED, Lappe JM, Heaney RP
PloS one · 86 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Health and Human Services
- Empresa
- Bio-Tech Pharmacal
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (R01 AG014683); National Institute on Aging (AG14683-01A2)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-04-06 · PLoS One · vol. 11 · número 4 · pág. e0152441
- Editorial
- Public Library of Science
- Citado
- 111 citas · más que el 99% de estudios similares · 13.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Thyroid Cancer Diagnosis and Treatment · Biotin and Related Studies
- Palabras clave
- Medicine, Cohort, Prospective cohort study, Internal medicine, Cancer, Incidence (geometry), Cohort study, Proportional hazards model, Gastroenterology
- MeSH
- humans, neoplasms, vitamin d, incidence, risk factors, prospective studies, aged, middle aged, female
8 autores
- Sharon L. McDonnell🇺🇸 · autor de correspondenciaGrassrootsHealth
- Carole A. Baggerly🇺🇸GrassrootsHealth
- Christine French🇺🇸GrassrootsHealth
- Leo L. Baggerly🇺🇸GrassrootsHealth
- Cedric F. Garland🇺🇸University of California San Diego
- Edward Doerr Gorham🇺🇸University of California San Diego
- Joan M. Lappe🇺🇸Creighton University
- Robert P. Heaney🇺🇸Creighton University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Higher serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with a lower risk of multiple cancer types across a range of 25(OH)D concentrations.
Objectives
To investigate whether the previously reported inverse association between 25(OH)D and cancer risk could be replicated, and if a 25(OH)D response region could be identified among women aged 55 years and older across a broad range of 25(OH)D concentrations.
Methods
Data from two cohorts representing different median 25(OH)D concentrations were pooled to afford a broader range of 25(OH)D concentrations than either cohort alone: the Lappe cohort (N = 1,169), a randomized clinical trial cohort (median 25(OH)D = 30 ng/ml) and the GrassrootsHealth cohort (N = 1,135), a prospective cohort (median 25(OH)D = 48 ng/ml). Cancer incidence over a multi-year period (median: 3.9 years) was compared according to 25(OH)D concentration. Kaplan-Meier plots were developed and the association between 25(OH)D and cancer risk was examined with multivariate Cox regression using multiple 25(OH)D measurements and spline functions. The study included all invasive cancers excluding skin cancer.
Results
Age-adjusted cancer incidence across the combined cohort (N = 2,304) was 840 cases per 100,000 person-years (1,020 per 100,000 person-years in the Lappe cohort and 722 per 100,000 person-years in the GrassrootsHealth cohort). Incidence was lower at higher concentrations of 25(OH)D. Women with 25(OH)D concentrations ≥40 ng/ml had a 67% lower risk of cancer than women with concentrations <20 ng/ml (HR = 0.33, 95% CI = 0.12-0.90).
Conclusions
25(OH)D concentrations ≥40 ng/ml were associated with substantial reduction in risk of all invasive cancers combined.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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