Supplementation with Folic Acid, but Not Creatine, Increases Plasma Betaine, Decreases Plasma Dimethylglycine, and Prevents a Decrease in Plasma Choline in Arsenic-Exposed Bangladeshi Adults
Hall MN, Howe CG, Liu X, Caudill MA, Malysheva O, Ilievski V, Lomax-Luu AM, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV
The Journal of nutrition · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NIH Clinical Center
- Gobierno
- NIH
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R01 CA133595); National Institute of Environmental Health Sciences (R01 ES017875); NIH Clinical Center (T32 ES007322); NIH Clinical Center (R01 CA133595); National Institute of Environmental Health Sciences (P42ES010349); National Institute of Environmental Health Sciences (R00ES018890); National Institute of Environmental Health Sciences (#T32ES007322); NIH Clinical Center (R01 ES017875); NIH Clinical Center (R00 ES0188990); National Institute of Environmental Health Sciences (F31 ES025100); NIH Clinical Center (P42 ES010349); NIH Clinical Center (F31 ES025100); National Institute of Environmental Health Sciences (P30ES009089)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2016-04-07 · J Nutr · vol. 146 · número 5 · págs. 1062–1067
- Editorial
- Elsevier BV
- Citado
- 15 citas · más que el 80% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Arsenic contamination and mitigation · Folate and B Vitamins Research · Heavy Metal Exposure and Toxicity
- Palabras clave
- folic acid supplementation, creatine supplementation, arsenic exposure, dimethylglycine, plasma choline, one-carbon metabolism, arsenic excretion, nutrition interventions, Bangladeshi adults, urinary arsenic excretion
- MeSH
- humans, arsenic, choline, creatine, betaine, folic acid, vitamin b complex, sarcosine, environmental exposure, dietary supplements, adult, middle aged, bangladesh, female, male, tandem mass spectrometry, young adult
14 autores
- Megan N. Hall🇺🇸 · autor de correspondenciaColumbia University
- Caitlin G. Howe🇺🇸Columbia University
- Xinhua Liu🇺🇸Columbia University
- Marie A. Caudill🇺🇸Cornell University
- Olga Malysheva🇺🇸Cornell University
- Vesna Ilievski🇺🇸Columbia University
- Angela M. Lomax-Luu🇺🇸Columbia University
- Faruque Parvez🇺🇸Columbia University
- Abu B Siddique🇺🇸Columbia University
- Hasan Shahriar🇺🇸Columbia University
- Mohammad Nasir Uddin🇺🇸Columbia University
- Tariqul Islam🇺🇸Columbia University
- Joseph H. Graziano🇺🇸Columbia University
- Mary V. Gamble🇺🇸Columbia University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Folic acid (FA) supplementation facilitates urinary excretion of arsenic, a human carcinogen. A better understanding of interactions between one-carbon metabolism intermediates may improve the ability to design nutrition interventions that further facilitate arsenic excretion.
Objective
The objective was to determine if FA and/or creatine supplementation increase choline and betaine and decrease dimethylglycine (DMG).
Methods
We conducted a secondary analysis of the Folic Acid and Creatine Trial, a randomized trial in arsenic-exposed Bangladeshi adults (n = 605, aged 24-55 y, 50.3% male) who received arsenic-removal water filters. We examined treatment effects of FA and/or creatine supplementation on plasma choline, betaine, and DMG concentrations, measured by LC-tandem mass spectrometry at baseline and at week 12. Group comparisons were between 1) 400 and 800 μg FA/d (FA400 and FA800, respectively) compared with placebo, 2) creatine (3 g/d) compared with placebo, and 3) creatine plus FA400 compared with FA400.
Results
Choline decreased in the placebo group (-6.6%; 95% CI: -10.2%, -2.9%) but did not change in the FA groups (FA400: 2.5%; 95% CI: -0.9%, 6.1%; FA800: 1.4%; 95% CI: -2.5%, 5.5%; P < 0.05). Betaine did not change in the placebo group (-3.5%; 95% CI: -9.3%, 2.6%) but increased in the FA groups (FA400: 14.1%; 95% CI: 9.4%, 19.0%; FA800: 13.0%; 95% CI: 7.2%, 19.1%; P < 0.01). The decrease in DMG was greater in the FA groups (FA400: -26.7%; 95% CI: -30.9%, -22.2%; FA800: -27.8%; 95% CI: -31.8%, -23.4%) than in the placebo group (-12.3%; 95% CI: -18.1%, -6.2%; P < 0.01). The percentage change in choline, betaine, and DMG did not differ between creatine treatment arms and their respective reference groups.
Conclusion
Supplementation for 12 wk with FA, but not creatine, increases plasma betaine, decreases plasma DMG, and prevents a decrease in plasma choline in arsenic-exposed Bangladeshi adults. This trial was registered at clinicaltrials.gov as NCT01050556.
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