Dose-response relationship between dietary magnesium intake and cardiovascular mortality: A systematic review and dose-based meta-regression analysis of prospective studies
Fang X, Liang C, Li M, Montgomery S, Fall K, Aaseth J, Cao Y
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 38 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-03-31 · J Trace Elem Med Biol · vol. 38 · págs. 64–73
- Editorial
- Elsevier BV
- Citado
- 52 citas · más que el 74% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Nutritional Studies and Diet · Magnesium Oxide Properties and Applications
- Palabras clave
- dietary magnesium, cardiovascular mortality, dose-response relationship, cardiovascular disease, sex differences, magnesium supplementation, cause-specific mortality
- MeSH
- humans, cardiovascular diseases, magnesium, survival analysis, sex characteristics, dose-response relationship, drug, dietary supplements, united states
7 autores
- Xin Lei Fang🇸🇪Karolinska Institutet
- Chun Liang🇨🇳Second Military Medical University; Shanghai Changzheng Hospital
- Mei Li🇨🇳Second Military Medical University; Shanghai Changzheng Hospital
- Scott Montgomery🇸🇪🇬🇧Karolinska University Hospital; Örebro University; Karolinska Institutet; University College London
- Katja Fall🇸🇪Karolinska University Hospital; Örebro University; Karolinska Institutet
- Jan Aaseth🇳🇴Innlandet Hospital Trust; Hedmark University College
- Yang Cao🇸🇪 · autor de correspondenciaÖrebro University; Karolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although epidemiology studies have reported the relationship, including a dose-response relationship, between dietary magnesium intake and risk of cardiovascular disease (CVD), the risk for CVD mortality is inconclusive and the evidence for a dose-response relationship has not been summarized.
Objective
We conducted a systematic review and meta-analysis of prospective studies to summarize the evidence regarding the association of dietary magnesium intake with risk of CVD mortality and describe their dose-response relationship.
Design
We identified relevant studies by searching major scientific literature databases and grey literature resources from their inception to August 2015, and reviewed references lists of retrieved articles. We included population-based studies that reported mortality risks, i.e. relative risks (RRs), odds ratios (ORs) or hazard ratios (HRs) of CVD mortality or cause-specific CVD death. Linear dose-response relationships were assessed using random-effects meta-regression. Potential nonlinear associations were evaluated using restricted cubic splines.
Results
Out of 3002 articles, 9 articles from 8 independent studies met the eligibility criteria. These studies comprised 449,748 individuals and 10,313 CVD deaths. Compared with the lowest dietary magnesium consumption group in the population, the risk of CVD mortality was reduced by 16% in women and 8% in men. No significant linear dose-response relationship was found between increment in dietary magnesium intake and CVD mortality across all the studies. After adjusting for age and BMI, the risk of CVD mortality was reduced by 24-25% per 100mg/d increment in dietary magnesium intake in women of all the participants and in all the US participants.
Conclusion
Although the combined data confirm the role of dietary magnesium intake in reducing CVD mortality, the dose-response relationship was only found among women and in US population.
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