Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial
Joris PJ, Plat J, Bakker SJ, Mensink RP
The American journal of clinical nutrition · 65 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-04-07 · Am J Clin Nutr · vol. 103 · número 5 · págs. 1260–1266
- Editorial
- Elsevier BV
- Citado
- 98 citas · más que el 98% de estudios similares · 9.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Nutritional Studies and Diet
- Palabras clave
- magnesium supplementation, arterial stiffness, pulse wave velocity, overweight, obesity, cardiovascular risk, serum magnesium, urinary magnesium excretion, blood pressure, postmenopausal women, vascular function, dietary magnesium, ambulatory blood pressure monitoring, carotid-femoral pulse wave velocity, cardiovascular health, cardiometabolic risk markers
- MeSH
- humans, obesity, body weight, magnesium, creatinine, c-reactive protein, blood pressure monitoring, ambulatory, body mass index, double-blind method, blood pressure, dietary supplements, aged, middle aged, female, male, overweight, waist circumference, vascular stiffness, pulse wave analysis, biomarkers
4 autores
- Peter J. Joris🇳🇱 · autor de correspondenciaMaastricht University Medical Centre; Maastricht University
- Jogchum Plat🇳🇱Maastricht University Medical Centre; Maastricht University
- Stephan J. L. Bakker🇳🇱University Medical Center Groningen; University of Groningen
- Ronald P. Mensink🇳🇱Maastricht University Medical Centre; Maastricht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiologic studies have suggested a protective effect of magnesium intake on cardiovascular disease risk. However, intervention trials of magnesium supplementation on blood pressure and conventional cardiometabolic risk markers are inconsistent. Effects on vascular function markers related to cardiovascular disease risk have rarely been studied.
Objective
The objective was to evaluate the effects of long-term magnesium supplementation on arterial stiffness.
Design
We performed a 24-wk, randomized, double-blind, placebo-controlled intervention study. Fifty-two overweight and slightly obese individuals (30 men and 22 postmenopausal women, mean ± SD age: 62 ± 6 y) were randomly allocated to receive either 3 times daily magnesium (3 × 117 mg or 350 mg/d) or placebo capsules. Twenty-four-hour urine collections and 24-h ambulatory blood pressure assessments were performed at the start and end of the study. Carotid-to-femoral pulse wave velocity (PWVc-f) was assessed at baseline, after 12 wk, and at week 24.
Results
Serum magnesium concentrations did not differ after 12 wk but tended to increase after 24-wk magnesium supplementation compared with placebo by 0.02 mmol/L (95% CI: 0.00, 0.04 mmol/L; P = 0.09). Twenty-four-hour urinary magnesium excretion increased by 2.01 mmol (95% CI: 1.22, 2.93 mmol; P < 0.001) at week 24. PWVc-f was not changed after 12 wk (0.0 m/s; 95% CI: -0.6, 0.5 m/s; P = 0.90) but was improved in the magnesium compared with the placebo group by 1.0 m/s (95% CI: 0.4, 1.6 m/s; P = 0.001) after 24 wk. Office and 24-h ambulatory blood pressure levels were not changed. No adverse events were observed.
Conclusion
Our data indicate that a daily magnesium supplement of 350 mg for 24 wk in overweight and obese adults reduces arterial stiffness, as estimated by a decrease in PWVc-f, suggesting a potential mechanism by which an increased dietary magnesium intake beneficially affects cardiovascular health. This trial was registered at clinicaltrials.gov as NCT02235805.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.