Associations of intakes of magnesium and calcium and survival among women with breast cancer: results from Western New York Exposures and Breast Cancer (WEB) Study
Tao MH, Dai Q, Millen AE, Nie J, Edge SB, Trevisan M, Shields PG, Freudenheim JL
American journal of cancer research · 38 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- NCI NIH HHS
- Gobierno
- NIAAA NIH HHS
Según 2 financiadores declarados.
Publicación
- Publicado
- 2016-01-01 · Am J Cancer Res · vol. 6 · número 1 · págs. 105–13
- Editorial
- National Institutes of Health
- Citado
- 42 citas · más que el 86% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Hazard ratio, Breast cancer, Calcium, Proportional hazards model, Cancer, Cohort, Vitamin D and neurology, Physiology, Internal medicine, Magnesium, Cohort study, Confidence interval, Endocrinology, Gastroenterology, Chemistry
8 autores
- Meng Hua Tao🇺🇸University of North Texas; University of North Texas Health Science Center
- Qi Dai🇺🇸Vanderbilt University; Vanderbilt Health
- Amy E. Millen🇺🇸University at Buffalo, State University of New York
- Jing Nie🇺🇸University at Buffalo, State University of New York
- Stephen B. Edge🇺🇸Baptist Cancer Center
- Maurizio Trevisan🇺🇸City College of New York
- Peter G. Shields🇺🇸The Ohio State University
- Jo L. Freudenheim🇺🇸University at Buffalo, State University of New York
Resumen
El texto original del estudio, en el idioma en que se publicó.
Magnesium (Mg) and calcium (Ca) antagonizes each other in (re) absorption, cell cycle regulation, inflammation, and many other physiologic activities. However, few studies have investigated the association between magnesium and calcium intakes and breast cancer survival, and the interaction between calcium and magnesium intake. In a cohort of 1,170 women with primary, incident, and histologically confirmed breast cancer from Western New York State, we examined the relationship between intakes of these two minerals and survival. Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Mean follow-up time was 87.4 months after breast cancer diagnosis; there were 170 deaths identified. After adjustment for known prognostic factors, and intakes of energy, total vitamin D and total calcium, higher dietary intake of magnesium was inversely associated with risk of all-cause mortality (HR = 0.50, 95% CI, 0.28-0.90 for highest vs. lowest tertile; p trend = 0.02). Likewise, a marginal association was found for total Magnesium intake from foods and supplements combined (HR = 0.58, 95% CI, 0.31-1.08; p trend = 0.09). The inverse association of higher total magnesium intake with all-cause mortality was primarily presented among postmenopausal women and was stronger among women who had a high Ca:Mg intake ratio (>2.59). There were no clear associations for prognosis with intake of calcium. We found that magnesium intake alone may improve overall survival following breast cancer, and the association may be stronger among those with high Ca:Mg intake ratio.
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