Analysis of 25-Hydroxyvitamin D Status According to Age, Gender, and Seasonal Variation
Yu HJ, Kwon MJ, Woo HY, Park H
Journal of clinical laboratory analysis · 27 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-04-13 · J Clin Lab Anal · vol. 30 · número 6 · págs. 905–911
- Editorial
- Wiley
- Citado
- 45 citas · más que el 91% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Biotin and Related Studies · Thyroid Disorders and Treatments
- Palabras clave
- Vitamin D and neurology, Medicine, Demography, Internal medicine, Population, Endocrinology
- MeSH
- humans, vitamin d, analysis of variance, retrospective studies, longitudinal studies, seasons, aging, sex characteristics, adolescent, adult, aged, aged, 80 and over, middle aged, female, male, young adult, republic of korea
4 autores
- Hui‐Jin Yu🇰🇷Kangbuk Samsung Hospital; Sungkyunkwan University
- Min‐Jung Kwon🇰🇷Kangbuk Samsung Hospital; Sungkyunkwan University
- Hee‐Yeon Woo🇰🇷Kangbuk Samsung Hospital; Sungkyunkwan University
- Hyosoon Park🇰🇷Kangbuk Samsung Hospital; Sungkyunkwan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The effects of age, gender, and seasonal variation on human levels of 25-hydroxyvitamin D (25(OH)D) are not well understood. In this study, we aimed to investigate 25(OH)D status according to these factors in a Korean population.
Methods
A total of 303,943 serum 25(OH)D levels were measured using an electrochemiluminescence immunoassay between October 2011 and May 2014. Potential participants were ineligible for the study if they had significant renal, hepatic, or thyroid dysfunction, as well as any major ongoing disease that could influence serum 25(OH)D levels.
Results
A total of 95,137 subjects (49,662 men and 45,475 women) were included in this study. The mean 25(OH)D levels were higher in men (42.4 nmol/l) than in women (32.9 nmol/l, P 75 nmol/l. The highest mean 25(OH)D value was noted in individuals aged ≥70 for both genders. The proportion of those with 25(OH)D levels <50 nmol/l appeared to be higher among younger subjects (P < 0.001). Lastly, there were significant differences between 25(OH)D levels in individuals during summer to fall and winter to spring in both genders, indicating seasonal periodicity (P < 0.001).
Conclusions
Serum 25(OH)D status varied according to gender, age, and season. Therefore, analyses of vitamin D status require individualized gender, age, and seasonally adjusted thresholds. Clinicians should consider these factors when determining optimal serum 25(OH)D levels in clinical practice.
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